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PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination
http://hdl.handle.net/2237/00030167
http://hdl.handle.net/2237/00030167490b1276-9d9c-460e-86c5-5c29d60c939d
名前 / ファイル | ライセンス | アクション |
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20190509original_file_of_paper (9.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-05-10 | |||||
タイトル | ||||||
タイトル | PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination | |||||
言語 | en | |||||
著者 |
Peng, Yang
× Peng, Yang× Kajiyama, Hiroaki× Yuan, Hong× Nakamura, Kae× Yoshihara, Masato× Yokoi, Akira× Fujikake, Kayo× Yasui, Hiroaki× Yoshikawa, Nobuhisa× Suzuki, Shiro× Senga, Takeshi× Shibata, Kiyosumi× Kikkawa, Fumitaka |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ovarian cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer-associated mesothelial cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasminogen activator inhibitor-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal metastasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microenvironment | |||||
抄録 | ||||||
内容記述 | The mesothelium, covered by a continuous monolayer of mesothelial cells, is the first protective barrier against metastatic ovarian cancer. However, mesothelial cells release tumor-promoting factors that accelerate the process of peritoneal metastasis. We identified cancer-associated mesothelial cells (CAMs) that had tumor-promoting potential. Here, we found that plasminogen activator inhibitor-1 (PAI-1) induced the formation of CAMs, after which CAMs increasingly secreted the oncogenic factors interleukin-8 (IL-8) and C-X-C motif chemokine ligand 5 (CXCL5), further promoting the metastasis of ovarian cancer cells in a feedback loop. After the formation of CAMs, PAI-1 activated the nuclear factor kappa B (NFκB) pathway in the CAMs, thus transcriptionally upregulating the expression of the downstream NFκB targets IL-8 and CXCL5. Moreover, PAI-1 correlated with peritoneal metastasis in ovarian cancer patients and indicated a poor prognosis. In both ex vivo and in vivo models, after PAI-1 expression was knocked down, the metastasis of ovarian cancer cells decreased significantly. Therefore, targeting PAI-1 may provide a potential target for future therapeutics to prevent the formation of CAMs and alleviate peritoneal metastasis in ovarian cancer patients. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2020-02-01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.canlet.2018.10.027 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0304-3835 | |||||
書誌情報 |
en : Cancer Letters 巻 442, p. 181-192, 発行日 2019-02 |
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著者版フラグ | ||||||
値 | author |