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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study

http://hdl.handle.net/2237/00030205
e1e00ba3-e239-4c15-956a-e1935850ea77
名前 / ファイル ライセンス アクション
Therapeutic_Efficacy.pdf Therapeutic_Efficacy (269.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-05-13
タイトル
タイトル Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study
著者 Katsuno, Takayuki

× Katsuno, Takayuki

WEKO 91208

Katsuno, Takayuki

Search repository
Masuda, Tomohiro

× Masuda, Tomohiro

WEKO 91209

Masuda, Tomohiro

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Saito, Shoji

× Saito, Shoji

WEKO 91210

Saito, Shoji

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Kato, Noritoshi

× Kato, Noritoshi

WEKO 91211

Kato, Noritoshi

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Ishimoto, Takuji

× Ishimoto, Takuji

WEKO 91212

Ishimoto, Takuji

Search repository
Kato, Sawako

× Kato, Sawako

WEKO 91213

Kato, Sawako

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Kosugi, Tomoki

× Kosugi, Tomoki

WEKO 91214

Kosugi, Tomoki

Search repository
Tsuboi, Naotake

× Tsuboi, Naotake

WEKO 91215

Tsuboi, Naotake

Search repository
Kitamura, Hiroshi

× Kitamura, Hiroshi

WEKO 91216

Kitamura, Hiroshi

Search repository
Tsuzuki, Toyonori

× Tsuzuki, Toyonori

WEKO 91217

Tsuzuki, Toyonori

Search repository
Ito, Yasuhiko

× Ito, Yasuhiko

WEKO 91218

Ito, Yasuhiko

Search repository
Maruyama, Shoichi

× Maruyama, Shoichi

WEKO 91219

Maruyama, Shoichi

Search repository
権利
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Clinical and Experimental Nephrology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10157-018-1630-y”.
キーワード
主題Scheme Other
主題 Adult-onset
キーワード
主題Scheme Other
主題 Steroid-dependent nephrotic syndrome
キーワード
主題Scheme Other
主題 Frequently relapsing nephrotic syndrome
キーワード
主題Scheme Other
主題 Minimal change nephrotic syndrome
キーワード
主題Scheme Other
主題 Rituximab
抄録
内容記述 Background: Recent reports have described the efficacy of rituximab in treating steroid-dependent nephrotic syndrome (SDNS) in pediatric patients. However, few reports describe data regarding adult-onset SDNS. We investigated the efficacy of rituximab for the management of adult-onset SDNS. Methods: We performed a retrospective cohort study investigating eight patients with adult-onset SDNS who were treated with rituximab. Clinical data were obtained at the initiation of rituximab therapy. The primary outcomes evaluated were successful suppression of relapses and CD19+ cells after rituximab treatment. The corticosteroid- and immunosuppressant-sparing effect and adverse events were additionally evaluated. Results: All eight patients were diagnosed with minimal change nephrotic syndrome and received immunosuppressants in addition to corticosteroid. Total number of relapses was 10.5 times as a median value. Rituximab administration was repeated in two patients, whereas six received single-dose rituximab. Three of eight (37.5%) patients showed relapse after rituximab therapy. A rituximab-induced depletion in CD19+ cells noted initially was followed by their reappearance in all patients. There were cases with no relapse after the reappearance of CD19+ cells. The median relapse time pre- and post-rituximab therapy showed a decrease from 1 time/year (interquartile range [IQR] 1–3 times/year) to 0 time/year (IQR 0–1 time/year). Rituximab treatment induced a significant reduction in the required doses of corticosteroid and cyclosporine (P < 0.01). No serious adverse events were observed. Conclusion: Rituximab treatment was effective not only in childhood-onset but also in adult-onset SDNS. Further studies are needed to establish optimal treatment regimens.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020/02/01
内容記述タイプ Other
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10157-018-1630-y
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 1342-1751
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 1437-7799
書誌情報 Clinical and Experimental Nephrology

巻 23, 号 2, p. 207-214, 発行日 2019-02
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