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Treatment of male stress urinary incontinence using autologous adipose-derived regenerative cells: Long-term efficacy and safety
http://hdl.handle.net/2237/00030430
http://hdl.handle.net/2237/0003043036e11aa4-72a4-434a-aded-b496bfe02871
名前 / ファイル | ライセンス | アクション |
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ADRCs (308.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-06-13 | |||||
タイトル | ||||||
タイトル | Treatment of male stress urinary incontinence using autologous adipose-derived regenerative cells: Long-term efficacy and safety | |||||
言語 | en | |||||
著者 |
Gotoh, Momokazu
× Gotoh, Momokazu× Yamamoto, Tokunori× Shimizu, Shinobu× Matsukawa, Yoshihisa× Kato, Masashi× Majima, Tsuyoshi× Takai, Shun× Funahashi, Yasuhito× Toriyama, Kazuhiro |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is the peer reviewed version of the following article: [Gotoh, M. , Yamamoto, T. , Shimizu, S. , Matsukawa, Y. , Kato, M. , Majima, T. , Takai, S. , Funahashi, Y. and Toriyama, K. (2019), Treatment of male stress urinary incontinence using autologous adipose‐derived regenerative cells: Long‐term efficacy and safety. Int. J. Urol., 26: 400-405. doi:10.1111/iju.13886], which has been published in final form at [https://doi.org/10.1111/iju.13886]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adipose‐derived regenerative cells | |||||
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主題Scheme | Other | |||||
主題 | cell therapy | |||||
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主題Scheme | Other | |||||
主題 | male | |||||
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主題Scheme | Other | |||||
主題 | prostatectomy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | stress urinary incontinence | |||||
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内容記述タイプ | Abstract | |||||
内容記述 | Objectives: To investigate the long‐term efficacy and safety of periurethral injection of autologous adipose‐derived regenerative cells for the treatment of post‐prostatectomy stress urinary incontinence. Methods: A total of 13 patients with persistent stress urinary incontinence after prostate surgery (radical prostatectomy, 10 patients; holmium laser enucleation of the prostate, three patients) underwent periurethral injection of adipose‐derived regenerative cells and were followed up for >4 years. A 24‐h pad test was carried out for four consecutive days in each evaluation period, and changes in the mean daily leakage volume during the 4 days from baseline to 60 months after treatment were evaluated. Results: The mean follow‐up period was 69 months (range 55–72 months). The mean leakage volume/24 h in all patients changed from 260.7 g to 152.7 g. Urinary incontinence progressively improved up to 12 months after treatment in 10 patients, who maintained improvement up to the final assessment, with the mean daily leakage volume decreasing from 281.5 g to 119.0 g (reduction rate 57.7%). The other three patients showed no improvement at 1 year and at the final assessment. After the perioperative period, significant adverse events or prostate‐specific antigen increase were not observed during long‐term follow up. Conclusions: The present findings suggest that periurethral injection of autologous adipose‐derived regenerative cells is a safe and feasible treatment modality with long‐term efficacy for patients with male stress urinary incontinence caused by urethral sphincter deficiency. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ファイル公開:2020-03-03 | |||||
言語 | ja | |||||
出版者 | ||||||
出版者 | Wiley | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/iju.13886 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0919-8172 | |||||
書誌情報 |
en : International Journal of Urology 巻 26, 号 3, p. 400-405, 発行日 2019-03-03 |
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著者版フラグ | ||||||
値 | author |