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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis

http://hdl.handle.net/2237/00030483
http://hdl.handle.net/2237/00030483
99423296-95de-4576-830f-2f4d9f0de970
名前 / ファイル ライセンス アクション
IJRD_R1_Manuscript_clean_180718.pdf IJRD_R1_Manuscript_clean_180718 (201.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-06-24
タイトル
タイトル Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis
言語 en
著者 Asai, Shuji

× Asai, Shuji

WEKO 92256

en Asai, Shuji

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Nagai, Kaoru

× Nagai, Kaoru

WEKO 92257

en Nagai, Kaoru

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Takahashi, Nobunori

× Takahashi, Nobunori

WEKO 92258

en Takahashi, Nobunori

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Watanabe, Tatsuo

× Watanabe, Tatsuo

WEKO 92259

en Watanabe, Tatsuo

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Matsumoto, Takuya

× Matsumoto, Takuya

WEKO 92260

en Matsumoto, Takuya

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Asai, Nobuyuki

× Asai, Nobuyuki

WEKO 92261

en Asai, Nobuyuki

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Sobue, Yasumori

× Sobue, Yasumori

WEKO 92262

en Sobue, Yasumori

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Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 92263

en Ishiguro, Naoki

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Kojima, Toshihisa

× Kojima, Toshihisa

WEKO 92264

en Kojima, Toshihisa

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Asai, S, Nagai, K, Takahashi, N, et al. Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis. Int J Rheum Dis. 2019; 22: 207– 213. https://doi.org/10.1111/apl.13380], which has been published in final form at [https://doi.org/10.1111/1756-185X.13380]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
キーワード
主題Scheme Other
主題 gastrointestinal symptoms
キーワード
主題Scheme Other
主題 methotrexate
キーワード
主題Scheme Other
主題 patient‐reported outcomes
キーワード
主題Scheme Other
主題 quality of life
キーワード
主題Scheme Other
主題 rheumatoid arthritis
抄録
内容記述タイプ Abstract
内容記述 Aim: This study aimed to determine the influence of methotrexate (MTX) on gastrointestinal (GI) symptoms in patients with rheumatoid arthritis (RA). Methods: This cross‐sectional study examined 529 consecutive patients with RA receiving oral MTX in our department between April 1 and September 30, 2017. GI symptoms were evaluated by the Gastrointestinal Symptom Rating Scale (GSRS); a score of ≥2 was considered “symptomatic.” Prevalence of GI symptoms was compared between patients receiving ≤8 mg/wk (low‐dose) vs >8 mg/wk (high‐dose) of MTX. Results: Of our study population, 313 (59%) received low‐dose MTX at a median (interquartile range) dose of 6 (6‐8) mg/wk, whereas 216 (41%) received high‐dose MTX at a median dose of 12 (10‐12) mg/wk. Relative to the low‐dose MTX group, the high‐dose MTX group exhibited a higher prevalence of reflux (32% vs 24%, P = 0.043) and abdominal pain (28% vs 18%, P = 0.007). There was no significant group‐dependent difference in the prevalence of indigestion, diarrhea or constipation. Multivariate logistic regression analysis revealed that high‐dose MTX (>8 mg/wk) was independently associated with reflux (odds ratio [OR]: 1.62, 95% confidence interval [CI]: 1.07‐2.43) and abdominal pain (OR: 1.60, 95% CI: 1.04‐2.43), and that the ORs for reflux and abdominal pain among those receiving high‐dose MTX (>8 mg/wk) were similar to those using nonsteroidal anti‐inflammatory drugs. Conclusion: High‐dose MTX is independently associated with the prevalence of upper GI symptoms in Japanese patients with RA.
言語 en
内容記述
内容記述タイプ Other
内容記述 ファイル公開:2020-02-01
言語 ja
出版者
出版者 Wiley
言語 en
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/1756-185X.13380
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1756-1841
書誌情報 en : International Journal of Rheumatic Diseases

巻 22, 号 2, p. 207-213, 発行日 2019-02
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