{"_buckets": {"deposit": "6fb87c36-16d1-4dfc-adff-9051460cb847"}, "_deposit": {"id": "28287", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28287"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00028287", "sets": ["501"]}, "author_link": ["92256", "92257", "92258", "92259", "92260", "92261", "92262", "92263", "92264"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "213", "bibliographicPageStart": "207", "bibliographicVolumeNumber": "22", "bibliographic_titles": [{"bibliographic_title": "International Journal of Rheumatic Diseases", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Aim: This study aimed to determine the influence of methotrexate (MTX) on gastrointestinal (GI) symptoms in patients with rheumatoid arthritis (RA). Methods: This cross‐sectional study examined 529 consecutive patients with RA receiving oral MTX in our department between April 1 and September 30, 2017. GI symptoms were evaluated by the Gastrointestinal Symptom Rating Scale (GSRS); a score of ≥2 was considered “symptomatic.” Prevalence of GI symptoms was compared between patients receiving ≤8 mg/wk (low‐dose) vs \u003e8 mg/wk (high‐dose) of MTX. Results: Of our study population, 313 (59%) received low‐dose MTX at a median (interquartile range) dose of 6 (6‐8) mg/wk, whereas 216 (41%) received high‐dose MTX at a median dose of 12 (10‐12) mg/wk. Relative to the low‐dose MTX group, the high‐dose MTX group exhibited a higher prevalence of reflux (32% vs 24%, P = 0.043) and abdominal pain (28% vs 18%, P = 0.007). There was no significant group‐dependent difference in the prevalence of indigestion, diarrhea or constipation. Multivariate logistic regression analysis revealed that high‐dose MTX (\u003e8 mg/wk) was independently associated with reflux (odds ratio [OR]: 1.62, 95% confidence interval [CI]: 1.07‐2.43) and abdominal pain (OR: 1.60, 95% CI: 1.04‐2.43), and that the ORs for reflux and abdominal pain among those receiving high‐dose MTX (\u003e8 mg/wk) were similar to those using nonsteroidal anti‐inflammatory drugs. Conclusion: High‐dose MTX is independently associated with the prevalence of upper GI symptoms in Japanese patients with RA.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "ファイル公開：2020-02-01", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/1756-185X.13380", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: [Asai, S, Nagai, K, Takahashi, N, et al. Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis. Int J Rheum Dis. 2019; 22: 207– 213. https://doi.org/10.1111/apl.13380], which has been published in final form at [https://doi.org/10.1111/1756-185X.13380]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "1756-1841", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Asai, Shuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92256", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagai, Kaoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92257", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Nobunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92258", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Tatsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92259", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Takuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92260", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asai, Nobuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92261", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sobue, Yasumori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92262", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishiguro, Naoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92263", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kojima, Toshihisa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "92264", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-02-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "IJRD_R1_Manuscript_clean_180718.pdf", "filesize": [{"value": "201.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 201000.0, "url": {"label": "IJRD_R1_Manuscript_clean_180718", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/28287/files/IJRD_R1_Manuscript_clean_180718.pdf"}, "version_id": "47f9517d-4508-4ed9-9151-8aa1f14ed84b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "gastrointestinal symptoms", "subitem_subject_scheme": "Other"}, {"subitem_subject": "methotrexate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "patient‐reported outcomes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "quality of life", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rheumatoid arthritis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/00030483", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-24"}, "publish_date": "2019-06-24", "publish_status": "0", "recid": "28287", "relation": {}, "relation_version_is_last": true, "title": ["Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis"], "weko_shared_id": -1}