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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Reactivation of human herpesviruses 6 and 7 in Kawasaki disease

http://hdl.handle.net/2237/00030818
http://hdl.handle.net/2237/00030818
32accf3b-4aea-474e-82fb-42a494fc88c7
名前 / ファイル ライセンス アクション
MR_Kawano_repository.pdf MR_Kawano_repository (314.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-10-18
タイトル
タイトル Reactivation of human herpesviruses 6 and 7 in Kawasaki disease
言語 en
著者 Kawano, Yoshihiko

× Kawano, Yoshihiko

WEKO 93772

en Kawano, Yoshihiko

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Kawada, Jun-ichi

× Kawada, Jun-ichi

WEKO 93773

en Kawada, Jun-ichi

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Nagai, Noriko

× Nagai, Noriko

WEKO 93774

en Nagai, Noriko

Search repository
Ito, Yoshinori

× Ito, Yoshinori

WEKO 93775

en Ito, Yoshinori

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Modern Rheumatology on 05/09/2018, available online: http://www.tandfonline.com/10.1080/14397595.2018.1510758.
キーワード
主題Scheme Other
主題 Human herpesvirus 6
キーワード
主題Scheme Other
主題 human herpesvirus 7
キーワード
主題Scheme Other
主題 Kawasaki disease
抄録
内容記述 Objectives: Kawasaki disease (KD) is one of the most common childhood vasculitides. Some serological studies have suggested an etiological relationship between KD and human herpesvirus (HHV)-6 or HHV-7. However, primary or reactivated HHV-6 and -7 has not been fully investigated in patients with KD. Methods: Twenty-three patients with KD were prospectively enrolled in this study. Peripheral blood was collected in the acute and convalescence phases, and HHV-6 and -7 viral loads were measured by real-time PCR. Results: In the acute phase, HHV-6 and -7 DNA was detected in 7 (30%) patients each, compared to 13 (57%) and 9 (39%) patients in the convalescence phase, respectively. HHV-6 and -7 DNA loads were significantly higher in the convalescence phase than in the acute phase. Significant increases in HHV-6 and -7 DNA loads were not observed in disease control patients. Taking into account HHV-6 and -7 serostatus, reactivation of HHV-6 and -7 was observed in 7 and 9 patients, respectively. KD patients with HHV-6 reactivation showed higher C-reactive protein levels and more frequently required steroid therapies than patients without reactivation. Conclusion: HHV-6 and -7 reactivation is frequent in KD patients. HHV-6 reactivation might exacerbate the severity of KD.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 Published online: 05 Sep 2018
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Taylor & Francis
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1080/14397595.2018.1510758
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1439-7595
書誌情報 en : Modern Rheumatology

巻 29, 号 4, p. 651-655, 発行日 2019
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