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Reactivation of human herpesviruses 6 and 7 in Kawasaki disease
http://hdl.handle.net/2237/00030818
http://hdl.handle.net/2237/0003081832accf3b-4aea-474e-82fb-42a494fc88c7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
MR_Kawano_repository (314.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-10-18 | |||||
| タイトル | ||||||
| タイトル | Reactivation of human herpesviruses 6 and 7 in Kawasaki disease | |||||
| 言語 | en | |||||
| 著者 |
Kawano, Yoshihiko
× Kawano, Yoshihiko× Kawada, Jun-ichi× Nagai, Noriko× Ito, Yoshinori |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Modern Rheumatology on 05/09/2018, available online: http://www.tandfonline.com/10.1080/14397595.2018.1510758. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Human herpesvirus 6 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | human herpesvirus 7 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Kawasaki disease | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Kawasaki disease (KD) is one of the most common childhood vasculitides. Some serological studies have suggested an etiological relationship between KD and human herpesvirus (HHV)-6 or HHV-7. However, primary or reactivated HHV-6 and -7 has not been fully investigated in patients with KD. Methods: Twenty-three patients with KD were prospectively enrolled in this study. Peripheral blood was collected in the acute and convalescence phases, and HHV-6 and -7 viral loads were measured by real-time PCR. Results: In the acute phase, HHV-6 and -7 DNA was detected in 7 (30%) patients each, compared to 13 (57%) and 9 (39%) patients in the convalescence phase, respectively. HHV-6 and -7 DNA loads were significantly higher in the convalescence phase than in the acute phase. Significant increases in HHV-6 and -7 DNA loads were not observed in disease control patients. Taking into account HHV-6 and -7 serostatus, reactivation of HHV-6 and -7 was observed in 7 and 9 patients, respectively. KD patients with HHV-6 reactivation showed higher C-reactive protein levels and more frequently required steroid therapies than patients without reactivation. Conclusion: HHV-6 and -7 reactivation is frequent in KD patients. HHV-6 reactivation might exacerbate the severity of KD. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Published online: 05 Sep 2018 | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/14397595.2018.1510758 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1439-7595 | |||||
| 書誌情報 |
en : Modern Rheumatology 巻 29, 号 4, p. 651-655, 発行日 2019 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
