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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

http://hdl.handle.net/2237/00030917
http://hdl.handle.net/2237/00030917
e8545007-9195-4d58-b017-6260a3d2eb21
名前 / ファイル ライセンス アクション
20190315_draft 20190315_draft revised (304.4 kB)
Figure Figure 1 (8.3 kB)
Figure Figure 2 (96.6 kB)
Figure Figure 3 (49.0 kB)
Figure Figure 4 (38.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-11-20
タイトル
タイトル Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region
言語 en
著者 Miyauchi, Tomoya

× Miyauchi, Tomoya

WEKO 94353

en Miyauchi, Tomoya

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Tokura, Tatsuya

× Tokura, Tatsuya

WEKO 94354

en Tokura, Tatsuya

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Kimura, Hiroyuki

× Kimura, Hiroyuki

WEKO 94355

en Kimura, Hiroyuki

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Ito, Mikiko

× Ito, Mikiko

WEKO 94356

en Ito, Mikiko

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Umemura, Eri

× Umemura, Eri

WEKO 94357

en Umemura, Eri

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Sato (Boku), Aiji

× Sato (Boku), Aiji

WEKO 94358

en Sato (Boku), Aiji

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Nagashima, Wataru

× Nagashima, Wataru

WEKO 94359

en Nagashima, Wataru

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Tonoike, Takashi

× Tonoike, Takashi

WEKO 94360

en Tonoike, Takashi

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Yamamoto, Yasuko

× Yamamoto, Yasuko

WEKO 94361

en Yamamoto, Yasuko

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Saito, Kuniaki

× Saito, Kuniaki

WEKO 94362

en Saito, Kuniaki

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Kurita, Kenichi

× Kurita, Kenichi

WEKO 94363

en Kurita, Kenichi

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Ozaki, Norio

× Ozaki, Norio

WEKO 94364

en Ozaki, Norio

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [ Miyauchi, T, Tokura, T, Kimura, H, et al. Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. Hum Psychopharmacol Clin Exp. 2019; 34:e2698. https://doi.org/10.1002/hup.2698], which has been published in final form at [https://doi.org/10.1002/hup.2698]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
キーワード
主題Scheme Other
主題 atypical odontalgia
キーワード
主題Scheme Other
主題 burning mouth syndrome
キーワード
主題Scheme Other
主題 chemokines
キーワード
主題Scheme Other
主題 cytokines
キーワード
主題Scheme Other
主題 neuroinflammation
キーワード
主題Scheme Other
主題 somatic symptom disorder with predominant pain
抄録
内容記述 Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation‐related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12‐week post‐treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)‐1β (p < .0001), IL‐1 receptor antagonist (p < .001), IL‐6 (p < .0001), macrophage inflammatory protein‐1β (p < .0001), and platelet‐derived growth factor‐bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p < .001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein‐1, and vascular endothelial growth factor decreased significantly with treatment (p < .001, .022, and .029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020-07-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/hup.2698
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0885-6222
書誌情報 en : Human Psychopharmacology: Clinical and Experimental

巻 34, 号 4, p. e2698, 発行日 2019-07
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