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Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region
http://hdl.handle.net/2237/00030917
http://hdl.handle.net/2237/00030917e8545007-9195-4d58-b017-6260a3d2eb21
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-11-20 | |||||
タイトル | ||||||
タイトル | Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region | |||||
言語 | en | |||||
著者 |
Miyauchi, Tomoya
× Miyauchi, Tomoya× Tokura, Tatsuya× Kimura, Hiroyuki× Ito, Mikiko× Umemura, Eri× Sato (Boku), Aiji× Nagashima, Wataru× Tonoike, Takashi× Yamamoto, Yasuko× Saito, Kuniaki× Kurita, Kenichi× Ozaki, Norio |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is the peer reviewed version of the following article: [ Miyauchi, T, Tokura, T, Kimura, H, et al. Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. Hum Psychopharmacol Clin Exp. 2019; 34:e2698. https://doi.org/10.1002/hup.2698], which has been published in final form at [https://doi.org/10.1002/hup.2698]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | atypical odontalgia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | burning mouth syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemokines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytokines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuroinflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | somatic symptom disorder with predominant pain | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation‐related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12‐week post‐treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)‐1β (p < .0001), IL‐1 receptor antagonist (p < .001), IL‐6 (p < .0001), macrophage inflammatory protein‐1β (p < .0001), and platelet‐derived growth factor‐bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p < .001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein‐1, and vascular endothelial growth factor decreased significantly with treatment (p < .001, .022, and .029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ファイル公開:2020-07-01 | |||||
言語 | ja | |||||
出版者 | ||||||
出版者 | Wiley | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/hup.2698 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0885-6222 | |||||
書誌情報 |
en : Human Psychopharmacology: Clinical and Experimental 巻 34, 号 4, p. e2698, 発行日 2019-07 |
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著者版フラグ | ||||||
値 | author |