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Peel-off resection of the pituitary gland for functional pituitary adenomas: pathological significance and impact on pituitary function
http://hdl.handle.net/2237/00031024
http://hdl.handle.net/2237/00031024cc56199f-b23a-45da-9d3b-1e54195c9b7f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Manuscript (194.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-20 | |||||
| タイトル | ||||||
| タイトル | Peel-off resection of the pituitary gland for functional pituitary adenomas: pathological significance and impact on pituitary function | |||||
| 言語 | en | |||||
| 著者 |
Nagata, Yuichi
× Nagata, Yuichi× Takeuchi, Kazuhito× Yamamoto, Taiki× Ishikawa, Takayuki× Kawabata, Teppei× Shimoyama, Yoshie× Inoshita, Naoko× Wakabayashi, Toshihiko |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [Pituitary]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11102-019-00980-w”. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pituitary resection | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Transsphenoidal surgery | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pseudocapsule | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pituitary adenoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Acromegaly | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cushing disease | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Functional pituitary adenomas (FPAs) lacking a well-defined pseudocapsule can invade the adjacent pituitary gland. In such situations, peel-off resection of the adjacent pituitary gland after selective adenomectomy might lead to complete tumor removal, resulting in optimal endocrinological outcomes. Here, we present the significance of peel-off resection of the pituitary gland in patients with FPA in whom complete extracapsular tumor removal cannot be achieved. Methods: We performed a retrospective review of 21 patients with FPA who underwent transsphenoidal surgery (TSS). After selective adenomectomy, peel-off resection of the adjacent pituitary gland was performed in 13 patients because complete extracapsular resection could not be achieved, while peel-off resection was not performed in the remaining 8 patients because complete extracapsular resection was accomplished. The clinical outcomes of these groups were compared. The pituitary tissues obtained by peel-off resection were pathologically examined for tumor cells. Results: Early postoperative biochemical remission was achieved in 20 patients (95.2%). Anterior pituitary functions were not aggravated postoperatively in any patient: however, transient diabetes insipidus (DI) occurred in 2 patients. There were no statistically significant differences in the clinical outcomes of the two groups. A pseudocapsule was pathologically detected in the adjacent anterior pituitary even in patients in whom no pseudocapsule was intraoperatively detected. Tumor cells were pathologically detected in 7 (58.3%) of 12 pituitary tissues examined. Conclusions: Peel-off resection of the pituitary gland, which can remove a small tumor cell remnant in the adjacent pituitary, might maximize the effectiveness of TSS with minimal impact on postoperative pituitary function. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2020/10/01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s11102-019-00980-w | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1386-341X | |||||
| 書誌情報 |
en : Pituitary 巻 22, 号 5, p. 507-513, 発行日 2019-10 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
