{"_buckets": {"deposit": "273c4ab9-3dd9-48fb-b49d-54d4c6715591"}, "_deposit": {"id": "28989", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28989"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00028989"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-09-20", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6459", "bibliographicPageEnd": "1313", "bibliographicPageStart": "1308", "bibliographicVolumeNumber": "365", "bibliographic_titles": [{"bibliographic_title": "Science"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone\u2013producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep. Hypothalamic MCH neurons densely innervated the dorsal hippocampus. Activation or inhibition of MCH neurons impaired or improved hippocampus-dependent memory, respectively. Activation of MCH nerve terminals in vitro reduced firing of hippocampal pyramidal neurons by increasing inhibitory inputs. Wake- and REM sleep\u2013active MCH neurons were distinct populations that were randomly distributed in the hypothalamus. REM sleep state\u2013dependent inhibition of MCH neurons impaired hippocampus-dependent memory without affecting sleep architecture or quality. REM sleep\u2013active MCH neurons in the hypothalamus are thus involved in active forgetting in the hippocampus.", "subitem_description_type": "Abstract"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "American Association for the Advancement of Science"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1126/science.aax9238", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u201cThis is the author\u2019s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science] on [v.365, n.6459, 20 Sep 2019], DOI: [10.1126/science.aai9057].\u201d"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0036-8075", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Izawa, Shuntaro"}], "nameIdentifiers": [{"nameIdentifier": "95226", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chowdhury, Srikanta"}], "nameIdentifiers": [{"nameIdentifier": "95227", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Toh"}], "nameIdentifiers": [{"nameIdentifier": "95228", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mukai, Yasutaka"}], "nameIdentifiers": [{"nameIdentifier": "95229", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "95230", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Ryo"}], "nameIdentifiers": [{"nameIdentifier": "95231", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohmura, Yu"}], "nameIdentifiers": [{"nameIdentifier": "95232", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizoguchi, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "95233", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "95234", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshioka, Mitsuhiro"}], "nameIdentifiers": [{"nameIdentifier": "95235", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Terao, Akira"}], "nameIdentifiers": [{"nameIdentifier": "95236", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kilduff, Thomas S."}], "nameIdentifiers": [{"nameIdentifier": "95237", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamanaka, Akihiro"}], "nameIdentifiers": [{"nameIdentifier": "95238", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-01-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Izawa_combined.pdf", "filesize": [{"value": "14.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 14400000.0, "url": {"label": "Izawa_combined", "url": "https://nagoya.repo.nii.ac.jp/record/28989/files/Izawa_combined.pdf"}, "version_id": "73311f34-747c-4d01-97e4-36a0e2dc044d"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "REM sleep\u2013active MCH neurons are involved in forgetting hippocampus-dependent memories", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "REM sleep\u2013active MCH neurons are involved in forgetting hippocampus-dependent memories"}]}, "item_type_id": "10", "owner": "1", "path": ["329/330/331"], "permalink_uri": "http://hdl.handle.net/2237/00031184", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2020-01-15"}, "publish_date": "2020-01-15", "publish_status": "0", "recid": "28989", "relation": {}, "relation_version_is_last": true, "title": ["REM sleep\u2013active MCH neurons are involved in forgetting hippocampus-dependent memories"], "weko_shared_id": null}