WEKO3
アイテム
REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories
http://hdl.handle.net/2237/00031184
http://hdl.handle.net/2237/00031184f78ccaed-13ff-4867-b714-8ea3ed13539f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Izawa_combined (14.4 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-15 | |||||
| タイトル | ||||||
| タイトル | REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories | |||||
| 言語 | en | |||||
| 著者 |
Izawa, Shuntaro
× Izawa, Shuntaro× Chowdhury, Srikanta× Miyazaki, Toh× Mukai, Yasutaka× Ono, Daisuke× Inoue, Ryo× Ohmura, Yu× Mizoguchi, Hiroyuki× Kimura, Kazuhiro× Yoshioka, Mitsuhiro× Terao, Akira× Kilduff, Thomas S.× Yamanaka, Akihiro |
|||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | “This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science] on [v.365, n.6459, 20 Sep 2019], DOI: [10.1126/science.aai9057].” | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone–producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep. Hypothalamic MCH neurons densely innervated the dorsal hippocampus. Activation or inhibition of MCH neurons impaired or improved hippocampus-dependent memory, respectively. Activation of MCH nerve terminals in vitro reduced firing of hippocampal pyramidal neurons by increasing inhibitory inputs. Wake- and REM sleep–active MCH neurons were distinct populations that were randomly distributed in the hypothalamus. REM sleep state–dependent inhibition of MCH neurons impaired hippocampus-dependent memory without affecting sleep architecture or quality. REM sleep–active MCH neurons in the hypothalamus are thus involved in active forgetting in the hippocampus. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | American Association for the Advancement of Science | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1126/science.aax9238 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0036-8075 | |||||
| 書誌情報 |
en : Science 巻 365, 号 6459, p. 1308-1313, 発行日 2019-09-20 |
|||||
| 著者版フラグ | ||||||
| 値 | author | |||||
