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  1. F100 環境医学研究所
  2. F100a 雑誌掲載論文
  3. 学術雑誌

REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories

http://hdl.handle.net/2237/00031184
http://hdl.handle.net/2237/00031184
f78ccaed-13ff-4867-b714-8ea3ed13539f
名前 / ファイル ライセンス アクション
Izawa_combined.pdf Izawa_combined (14.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-01-15
タイトル
タイトル REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories
言語 en
著者 Izawa, Shuntaro

× Izawa, Shuntaro

WEKO 95226

en Izawa, Shuntaro

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Chowdhury, Srikanta

× Chowdhury, Srikanta

WEKO 95227

en Chowdhury, Srikanta

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Miyazaki, Toh

× Miyazaki, Toh

WEKO 95228

en Miyazaki, Toh

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Mukai, Yasutaka

× Mukai, Yasutaka

WEKO 95229

en Mukai, Yasutaka

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Ono, Daisuke

× Ono, Daisuke

WEKO 95230

en Ono, Daisuke

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Inoue, Ryo

× Inoue, Ryo

WEKO 95231

en Inoue, Ryo

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Ohmura, Yu

× Ohmura, Yu

WEKO 95232

en Ohmura, Yu

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Mizoguchi, Hiroyuki

× Mizoguchi, Hiroyuki

WEKO 95233

en Mizoguchi, Hiroyuki

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Kimura, Kazuhiro

× Kimura, Kazuhiro

WEKO 95234

en Kimura, Kazuhiro

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Yoshioka, Mitsuhiro

× Yoshioka, Mitsuhiro

WEKO 95235

en Yoshioka, Mitsuhiro

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Terao, Akira

× Terao, Akira

WEKO 95236

en Terao, Akira

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Kilduff, Thomas S.

× Kilduff, Thomas S.

WEKO 95237

en Kilduff, Thomas S.

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Yamanaka, Akihiro

× Yamanaka, Akihiro

WEKO 95238

en Yamanaka, Akihiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science] on [v.365, n.6459, 20 Sep 2019], DOI: [10.1126/science.aai9057].”
抄録
内容記述 The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone–producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep. Hypothalamic MCH neurons densely innervated the dorsal hippocampus. Activation or inhibition of MCH neurons impaired or improved hippocampus-dependent memory, respectively. Activation of MCH nerve terminals in vitro reduced firing of hippocampal pyramidal neurons by increasing inhibitory inputs. Wake- and REM sleep–active MCH neurons were distinct populations that were randomly distributed in the hypothalamus. REM sleep state–dependent inhibition of MCH neurons impaired hippocampus-dependent memory without affecting sleep architecture or quality. REM sleep–active MCH neurons in the hypothalamus are thus involved in active forgetting in the hippocampus.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 American Association for the Advancement of Science
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1126/science.aax9238
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0036-8075
書誌情報 en : Science

巻 365, 号 6459, p. 1308-1313, 発行日 2019-09-20
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