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Structures and functions of penta-EF-hand calcium-binding proteins and their interacting partners: enigmatic relationships between ALG-2 and calpain-7
http://hdl.handle.net/2237/00031582
http://hdl.handle.net/2237/00031582b43cf3ac-28e0-4915-90de-ab7682f23546
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BBB-2020_mmaki (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-12 | |||||
| タイトル | ||||||
| タイトル | Structures and functions of penta-EF-hand calcium-binding proteins and their interacting partners: enigmatic relationships between ALG-2 and calpain-7 | |||||
| 言語 | en | |||||
| 著者 |
Maki, Masatoshi
× Maki, Masatoshi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Bioscience, Biotechnology, and Biochemistry on 09/12/2019, available online: http://www.tandfonline.com/10.1080/09168451.2019.1700099 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Calcium-binding protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | calpain | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ESCRT | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | penta-EF-hand | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | protease | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The penta-EF-hand (PEF) protein family includes ALG-2 (gene name, PDCD6) and its paralogs as well as classical calpain family members. ALG-2 is a prototypic PEF protein that is widely distributed in eukaryotes and interacts with a variety of proteins in a Ca2+-dependent manner. Mammalian ALG-2 and its interacting partners have various modulatory roles including roles in cell death, signal transduction, membrane repair, ER-to-Golgi vesicular transport, and RNA processing. Some ALG-2-interacting proteins are key factors that function in the endosomal sorting complex required for transport (ESCRT) system. On the other hand, mammalian calpain-7 (CAPN7) lacks the PEF domain but contains two microtubule-interacting and trafficking (MIT) domains in tandem. CAPN7 interacts with a subset of ESCRT-III proteins through the MIT domains and regulates EGF receptor downregulation. Structures and functions of ALG-2 and those of its interacting partners as well as relationships with the calpain family are reviewed in this article. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Published online: 09 Dec 2019 ファイル公開：2020/12/09 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/09168451.2019.1700099 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0916-8451 | |||||
| 書誌情報 |
en : Bioscience, Biotechnology, and Biochemistry 巻 84, 号 4, p. 651-660, 発行日 2020 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
