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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Identification of amino acids negatively affecting Fusarium trichothecene biosynthesis

http://hdl.handle.net/2237/00032178
http://hdl.handle.net/2237/00032178
90d3b746-fae1-4239-b2a5-677d581f489f
名前 / ファイル ライセンス アクション
Identification_of_amino_acids.pdf Identification_of_amino_acids (3.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-05-19
タイトル
タイトル Identification of amino acids negatively affecting Fusarium trichothecene biosynthesis
言語 en
著者 Shiobara, Takuya

× Shiobara, Takuya

WEKO 98999

en Shiobara, Takuya

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Nakajima, Yuichi

× Nakajima, Yuichi

WEKO 99000

en Nakajima, Yuichi

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Maeda, Kazuyuki

× Maeda, Kazuyuki

WEKO 99001

en Maeda, Kazuyuki

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Akasaka, Manami

× Akasaka, Manami

WEKO 99002

en Akasaka, Manami

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Kitou, Yoshiyuki

× Kitou, Yoshiyuki

WEKO 99003

en Kitou, Yoshiyuki

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Kanamaru, Kyoko

× Kanamaru, Kyoko

WEKO 99004

en Kanamaru, Kyoko

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Ohsato, Shuichi

× Ohsato, Shuichi

WEKO 99005

en Ohsato, Shuichi

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Kobayashi, Tetsuo

× Kobayashi, Tetsuo

WEKO 99006

en Kobayashi, Tetsuo

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Nishiuchi, Takumi

× Nishiuchi, Takumi

WEKO 99007

en Nishiuchi, Takumi

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Kimura, Makoto

× Kimura, Makoto

WEKO 99008

en Kimura, Makoto

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Antonie van Leeuwenhoek]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10482-018-1172-z”.
キーワード
主題Scheme Other
主題 AreA transcription factor
キーワード
主題Scheme Other
主題 Defined medium
キーワード
主題Scheme Other
主題 Fed-batch culture
キーワード
主題Scheme Other
主題 Mycotoxin biosynthesis
キーワード
主題Scheme Other
主題 Secondary metabolite
キーワード
主題Scheme Other
主題 Threonine metabolism
抄録
内容記述 Nitrogen sources in media have a significant impact on the onset of secondary metabolism in fungi. For transcriptional activation of many nitrogen catabolic genes, an AreA transcription factor is indispensable. This also holds true for Fusarium graminearum that produces trichothecenes, an important group of mycotoxin, in axenic culture. Despite the presence of numerous consensus AreA-binding sites in the promoters of Tri genes in the trichothecene cluster core region, the effect of medium amino acids on trichothecene biosynthesis is poorly understood. In this study, we examined the effect of certain amino acids, which were predicted to activate AreA function and increase Tri gene transcription, on trichothecene production in liquid culture. By frequent monitoring and adjustments in the pH of the culture medium, including replacement of the spent medium with fresh medium, we demonstrate the suppressive effects of the amino acids, used as the sole nitrogen source, on trichothecene biosynthesis. When the medium pH was maintained at 4.0, Gly, l-Ser, and l-Thr suppressed trichothecene production by F. graminearum. Enhanced trichothecene-inducing effects were observed when the medium pH was 3.5, with only l-Thr suppressing trichothecene synthesis.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10482-018-1172-z
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0003-6072
書誌情報 en : Antonie van Leeuwenhoek

巻 112, 号 3, p. 471-478, 発行日 2019-03-15
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