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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(2)

Contributions of residual hypoxemia to exercise hyperventilation in Fontan patients

https://doi.org/10.18999/nagjms.82.2.281
https://doi.org/10.18999/nagjms.82.2.281
8be57320-5428-4106-a043-9322e9ad1a18
名前 / ファイル ライセンス アクション
12_Okamura.pdf 12_Okamura.pdf (1.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-06-01
タイトル
タイトル Contributions of residual hypoxemia to exercise hyperventilation in Fontan patients
著者 Okamura, Yukiko

× Okamura, Yukiko

WEKO 99312

Okamura, Yukiko

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Kito, Machiko

× Kito, Machiko

WEKO 99313

Kito, Machiko

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Yasuda, Kazushi

× Yasuda, Kazushi

WEKO 99314

Yasuda, Kazushi

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Baba, Reizo

× Baba, Reizo

WEKO 99315

Baba, Reizo

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キーワード
主題Scheme Other
主題 Fontan
キーワード
主題Scheme Other
主題 exercise tolerance
キーワード
主題Scheme Other
主題 oxygen uptake efficiency slope
キーワード
主題Scheme Other
主題 maximal oxygen uptake
キーワード
主題Scheme Other
主題 ventilatory response
抄録
内容記述 It is unsettled whether increased exercise ventilation in Fontan subjects is due to increased pulmonary dead space or augmented ventilatory drive. Twenty-six Fontan patients underwent symptom-limited treadmill cardiopulmonary exercise testing. Two groups of age- and sex- matched subjects served as controls: the biventricularly repaired (Bi, n = 18), and the “true” control (C, n = 29) groups. Peak oxygen uptake (VO2peak) was not different among groups (41.0 +/– 8.4 ml/min/kg, 43.5 +/– 6.6 ml/min/kg, and 45.9 +/– 11.6 ml/min/kg for Fontan, Bi, and C groups, respectively, p = 0.16). Fontan subjects, however, showed steeper alveolar ventilation/carbon-dioxide (VA/VCO2) regression slope (35.5 +/– 5.3, 28.7 +/– 3.8, and 29.5 +/– 3.0 l/ml, for Fontan, Bi, and C groups, respectively, p<0.0001), and lower end-expiratory carbon-dioxide fraction (FetCO2VAT) at ventilatory threshold (VAT) (4.4 +/– 0.5%, 5.5 +/– 0.5%, and 5.5 +/– 0.4%, for Fontan, Bi, and C groups, respectively, p<0.001). The dead-space ventilation fraction at VAT was similar among groups (0.33 +/– 0.06, 0.33 +/– 0.04, 0.35 +/– 0.05 for Fontan, Bi, and C groups, respectively, p = 0.54). In Fontan subjects, arterial oxygen saturation at rest (SaO2rest) was correlated with VA/VCO2 regression slope (r = –0.41, p = 0.04) and with FetCO2VAT (p = –0.53, p<0.01). We conclude that Fontan patients show exercise hyperventilation due to augmented central and/or peripheral ventilatory drive, which is further augmented by residual hypoxemia.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.2.281
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/822.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 2, p. 281-289, 発行日 2020-05
著者版フラグ
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