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Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation
http://hdl.handle.net/2237/00032353
7ef79981-caf5-48d9-97d8-3261394e2a4c
名前 / ファイル | ライセンス | アクション | |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-12 | |||||
タイトル | ||||||
タイトル | Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation | |||||
著者 |
Kamoshita, Sonoko
× Kamoshita, Sonoko× Murata, Makoto× Koyama, Daisuke× Julamanee, Jakrawadee× Okuno, Shingo× Takagi, Erina× Miyao, Kotaro× Goto, Tatsunori× Ozawa, Yukiyasu× Miyamura, Koichi× Terakura, Seitaro× Nishida, Tetsuya× Kiyoi, Hitoshi |
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権利 | ||||||
権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [International Journal of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-019-02739-2”. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Graft-versus-host disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ACAT1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Single nucleotide polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Donor | |||||
抄録 | ||||||
内容記述 | Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing their cytotoxic function. In the present study, we investigated whether the presence of the ACAT1 single nucleotide polymorphism rs11545566 in transplant donors affected the risk of graft-versus-host disease (GVHD) in 116 adult patients who underwent bone marrow transplantation from human leukocyte antigen-identical sibling donors, and who received GVHD prophylaxis with short-term methotrexate and cyclosporine. The frequencies of the AA, AG, and GG genotypes in the donors were 31%, 45%, and 24%, respectively. The cumulative incidences of grade II–IV acute GVHD on day 100 in patients whose donors had AA vs. non-AA genotypes were 6% and 18%, respectively, and those of extensive chronic GVHD at 2 years were 7% and 32%, respectively. Multivariate analyses demonstrated that donor rs11545566 non-AA genotypes showed a trend toward a higher incidence of grade II–IV acute GVHD (P = 0.079), and were significantly associated with a higher incidence of extensive chronic GVHD (P = 0.021). These results suggest that donor ACAT1 rs11545566 genotype may be predictive of GVHD. | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2021/01/01 | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s12185-019-02739-2 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0925-5710 | |||||
書誌情報 |
International Journal of Hematology 巻 111, 号 1, p. 112-119, 発行日 2020-01 |
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著者版フラグ | ||||||
値 | author |