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Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation
http://hdl.handle.net/2237/00032353
http://hdl.handle.net/2237/000323537ef79981-caf5-48d9-97d8-3261394e2a4c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Murata_Int_J_Hematol2020 (354.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-12 | |||||
| タイトル | ||||||
| タイトル | Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation | |||||
| 言語 | en | |||||
| 著者 |
Kamoshita, Sonoko
× Kamoshita, Sonoko× Murata, Makoto× Koyama, Daisuke× Julamanee, Jakrawadee× Okuno, Shingo× Takagi, Erina× Miyao, Kotaro× Goto, Tatsunori× Ozawa, Yukiyasu× Miyamura, Koichi× Terakura, Seitaro× Nishida, Tetsuya× Kiyoi, Hitoshi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [International Journal of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-019-02739-2”. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Graft-versus-host disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ACAT1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Single nucleotide polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Transplantation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Donor | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing their cytotoxic function. In the present study, we investigated whether the presence of the ACAT1 single nucleotide polymorphism rs11545566 in transplant donors affected the risk of graft-versus-host disease (GVHD) in 116 adult patients who underwent bone marrow transplantation from human leukocyte antigen-identical sibling donors, and who received GVHD prophylaxis with short-term methotrexate and cyclosporine. The frequencies of the AA, AG, and GG genotypes in the donors were 31%, 45%, and 24%, respectively. The cumulative incidences of grade II–IV acute GVHD on day 100 in patients whose donors had AA vs. non-AA genotypes were 6% and 18%, respectively, and those of extensive chronic GVHD at 2 years were 7% and 32%, respectively. Multivariate analyses demonstrated that donor rs11545566 non-AA genotypes showed a trend toward a higher incidence of grade II–IV acute GVHD (P = 0.079), and were significantly associated with a higher incidence of extensive chronic GVHD (P = 0.021). These results suggest that donor ACAT1 rs11545566 genotype may be predictive of GVHD. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2021/01/01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s12185-019-02739-2 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0925-5710 | |||||
| 書誌情報 |
en : International Journal of Hematology 巻 111, 号 1, p. 112-119, 発行日 2020-01 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
