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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation

http://hdl.handle.net/2237/00032353
7ef79981-caf5-48d9-97d8-3261394e2a4c
名前 / ファイル ライセンス アクション
Murata_Int_J_Hematol2020.pdf Murata_Int_J_Hematol2020 (354.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-06-12
タイトル
タイトル Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation
著者 Kamoshita, Sonoko

× Kamoshita, Sonoko

WEKO 99622

Kamoshita, Sonoko

Search repository
Murata, Makoto

× Murata, Makoto

WEKO 99623

Murata, Makoto

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Koyama, Daisuke

× Koyama, Daisuke

WEKO 99624

Koyama, Daisuke

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Julamanee, Jakrawadee

× Julamanee, Jakrawadee

WEKO 99625

Julamanee, Jakrawadee

Search repository
Okuno, Shingo

× Okuno, Shingo

WEKO 99626

Okuno, Shingo

Search repository
Takagi, Erina

× Takagi, Erina

WEKO 99627

Takagi, Erina

Search repository
Miyao, Kotaro

× Miyao, Kotaro

WEKO 99628

Miyao, Kotaro

Search repository
Goto, Tatsunori

× Goto, Tatsunori

WEKO 99629

Goto, Tatsunori

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Ozawa, Yukiyasu

× Ozawa, Yukiyasu

WEKO 99630

Ozawa, Yukiyasu

Search repository
Miyamura, Koichi

× Miyamura, Koichi

WEKO 99631

Miyamura, Koichi

Search repository
Terakura, Seitaro

× Terakura, Seitaro

WEKO 99632

Terakura, Seitaro

Search repository
Nishida, Tetsuya

× Nishida, Tetsuya

WEKO 99633

Nishida, Tetsuya

Search repository
Kiyoi, Hitoshi

× Kiyoi, Hitoshi

WEKO 99634

Kiyoi, Hitoshi

Search repository
権利
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [International Journal of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-019-02739-2”.
キーワード
主題Scheme Other
主題 Graft-versus-host disease
キーワード
主題Scheme Other
主題 ACAT1
キーワード
主題Scheme Other
主題 Single nucleotide polymorphism
キーワード
主題Scheme Other
主題 Transplantation
キーワード
主題Scheme Other
主題 Donor
抄録
内容記述 Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing their cytotoxic function. In the present study, we investigated whether the presence of the ACAT1 single nucleotide polymorphism rs11545566 in transplant donors affected the risk of graft-versus-host disease (GVHD) in 116 adult patients who underwent bone marrow transplantation from human leukocyte antigen-identical sibling donors, and who received GVHD prophylaxis with short-term methotrexate and cyclosporine. The frequencies of the AA, AG, and GG genotypes in the donors were 31%, 45%, and 24%, respectively. The cumulative incidences of grade II–IV acute GVHD on day 100 in patients whose donors had AA vs. non-AA genotypes were 6% and 18%, respectively, and those of extensive chronic GVHD at 2 years were 7% and 32%, respectively. Multivariate analyses demonstrated that donor rs11545566 non-AA genotypes showed a trend toward a higher incidence of grade II–IV acute GVHD (P = 0.079), and were significantly associated with a higher incidence of extensive chronic GVHD (P = 0.021). These results suggest that donor ACAT1 rs11545566 genotype may be predictive of GVHD.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021/01/01
内容記述タイプ Other
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s12185-019-02739-2
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0925-5710
書誌情報 International Journal of Hematology

巻 111, 号 1, p. 112-119, 発行日 2020-01
著者版フラグ
値 author
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