{"_buckets": {"deposit": "344e9779-062b-4de2-9f33-ae78d25c9f23"}, "_deposit": {"id": "30167", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "30167"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00030167"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "119", "bibliographicPageStart": "112", "bibliographicVolumeNumber": "111", "bibliographic_titles": [{"bibliographic_title": "International Journal of Hematology"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing their cytotoxic function. In the present study, we investigated whether the presence of the ACAT1 single nucleotide polymorphism rs11545566 in transplant donors affected the risk of graft-versus-host disease (GVHD) in 116 adult patients who underwent bone marrow transplantation from human leukocyte antigen-identical sibling donors, and who received GVHD prophylaxis with short-term methotrexate and cyclosporine. The frequencies of the AA, AG, and GG genotypes in the donors were 31%, 45%, and 24%, respectively. The cumulative incidences of grade II\u2013IV acute GVHD on day 100 in patients whose donors had AA vs. non-AA genotypes were 6% and 18%, respectively, and those of extensive chronic GVHD at 2 years were 7% and 32%, respectively. Multivariate analyses demonstrated that donor rs11545566 non-AA genotypes showed a trend toward a higher incidence of grade II\u2013IV acute GVHD (P\u2009=\u20090.079), and were significantly associated with a higher incidence of extensive chronic GVHD (P\u2009=\u20090.021). These results suggest that donor ACAT1 rs11545566 genotype may be predictive of GVHD.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2021/01/01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s12185-019-02739-2", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u201cThis is a post-peer-review, pre-copyedit version of an article published in [International Journal of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-019-02739-2\u201d."}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0925-5710", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kamoshita, Sonoko"}], "nameIdentifiers": [{"nameIdentifier": "99622", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "99623", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koyama, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "99624", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Julamanee, Jakrawadee"}], "nameIdentifiers": [{"nameIdentifier": "99625", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okuno, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "99626", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takagi, Erina"}], "nameIdentifiers": [{"nameIdentifier": "99627", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyao, Kotaro"}], "nameIdentifiers": [{"nameIdentifier": "99628", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Goto, Tatsunori"}], "nameIdentifiers": [{"nameIdentifier": "99629", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozawa, Yukiyasu"}], "nameIdentifiers": [{"nameIdentifier": "99630", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyamura, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "99631", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Terakura, Seitaro"}], "nameIdentifiers": [{"nameIdentifier": "99632", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishida, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "99633", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyoi, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "99634", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Murata_Int_J_Hematol2020.pdf", "filesize": [{"value": "354.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 354500.0, "url": {"label": "Murata_Int_J_Hematol2020", "url": "https://nagoya.repo.nii.ac.jp/record/30167/files/Murata_Int_J_Hematol2020.pdf"}, "version_id": "b1059583-022c-4666-a2d4-6ee89280f07c"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Graft-versus-host disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ACAT1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Single nucleotide polymorphism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Transplantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Donor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00032353", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2020-06-12"}, "publish_date": "2020-06-12", "publish_status": "0", "recid": "30167", "relation": {}, "relation_version_is_last": true, "title": ["Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation"], "weko_shared_id": null}