{"_buckets": {"deposit": "344e9779-062b-4de2-9f33-ae78d25c9f23"}, "_deposit": {"id": "30167", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "30167"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00030167", "sets": ["501"]}, "author_link": ["99622", "99623", "99624", "99625", "99626", "99627", "99628", "99629", "99630", "99631", "99632", "99633", "99634"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "119", "bibliographicPageStart": "112", "bibliographicVolumeNumber": "111", "bibliographic_titles": [{"bibliographic_title": "International Journal of Hematology", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing their cytotoxic function. In the present study, we investigated whether the presence of the ACAT1 single nucleotide polymorphism rs11545566 in transplant donors affected the risk of graft-versus-host disease (GVHD) in 116 adult patients who underwent bone marrow transplantation from human leukocyte antigen-identical sibling donors, and who received GVHD prophylaxis with short-term methotrexate and cyclosporine. The frequencies of the AA, AG, and GG genotypes in the donors were 31%, 45%, and 24%, respectively. The cumulative incidences of grade II–IV acute GVHD on day 100 in patients whose donors had AA vs. non-AA genotypes were 6% and 18%, respectively, and those of extensive chronic GVHD at 2 years were 7% and 32%, respectively. Multivariate analyses demonstrated that donor rs11545566 non-AA genotypes showed a trend toward a higher incidence of grade II–IV acute GVHD (P = 0.079), and were significantly associated with a higher incidence of extensive chronic GVHD (P = 0.021). These results suggest that donor ACAT1 rs11545566 genotype may be predictive of GVHD.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "ファイル公開：2021/01/01", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s12185-019-02739-2", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "“This is a post-peer-review, pre-copyedit version of an article published in [International Journal of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-019-02739-2”.", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0925-5710", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kamoshita, Sonoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99622", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99623", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koyama, Daisuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99624", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Julamanee, Jakrawadee", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99625", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okuno, Shingo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99626", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takagi, Erina", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99627", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyao, Kotaro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99628", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Goto, Tatsunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99629", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozawa, Yukiyasu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99630", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyamura, Koichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99631", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Terakura, Seitaro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99632", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishida, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99633", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyoi, Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "99634", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-01-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Murata_Int_J_Hematol2020.pdf", "filesize": [{"value": "354.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 354500.0, "url": {"label": "Murata_Int_J_Hematol2020", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/30167/files/Murata_Int_J_Hematol2020.pdf"}, "version_id": "b1059583-022c-4666-a2d4-6ee89280f07c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Graft-versus-host disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ACAT1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Single nucleotide polymorphism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Transplantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Donor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/00032353", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-06-12"}, "publish_date": "2020-06-12", "publish_status": "0", "recid": "30167", "relation": {}, "relation_version_is_last": true, "title": ["Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation"], "weko_shared_id": -1}