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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(3)

Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis : role of macrophages and fibroblasts in the liver

https://doi.org/10.18999/nagjms.82.3.391
https://doi.org/10.18999/nagjms.82.3.391
e37cbe69-6991-40e4-8973-fadaceb536b0
名前 / ファイル ライセンス アクション
01_Itoh.pdf 01_Itoh.pdf (2.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-09-04
タイトル
タイトル Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis : role of macrophages and fibroblasts in the liver
著者 Itoh, Michiko

× Itoh, Michiko

WEKO 100992

Itoh, Michiko

Search repository
Ogawa, Yoshihiro

× Ogawa, Yoshihiro

WEKO 100993

Ogawa, Yoshihiro

Search repository
Suganami, Takayoshi

× Suganami, Takayoshi

WEKO 100994

Suganami, Takayoshi

Search repository
キーワード
主題Scheme Other
主題 chronic inflammation
キーワード
主題Scheme Other
主題 macrophages
キーワード
主題Scheme Other
主題 fibroblasts
抄録
内容記述 The pathological spectrum of nonalcoholic fatty liver disease includes simple steatosis and nonalcoholic steatohepatitis (NASH), the latter of which is the leading cause of cirrhosis and hepatocellular carcinoma. The available evidence shows that parenchymal cell injury and death trigger inflammation and tissue fibrosis. During the development of liver fibrosis, stromal cells dramatically changes in their cellular component and activation status responding to hepatocyte injury due to various etiologies. It is important to understand how cell death induces chronic inflammation and fibrosis, and the disease-specific macrophages and fibroblasts responsible for NASH development under metabolic stress. This review discusses recent progress in the understanding the pathogenesis of NASH, focusing on disease-specific macrophages and fibroblasts.
内容記述タイプ Abstract
内容記述
内容記述 This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (16H05171, 16KT0110, 16K08732, 17H05500, and 19K07475) and AMED-CREST (JP19gm1210009).
内容記述タイプ Other
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.3.391
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 3, p. 391-397, 発行日 2020-08
著者版フラグ
値 publisher
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