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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(3)

Therapeutic effect of adipose-derived regenerative cells on bladder function in rats with underactive bladder

https://doi.org/10.18999/nagjms.82.3.425
https://doi.org/10.18999/nagjms.82.3.425
2494052e-2397-4225-987e-dbd1ca783ada
名前 / ファイル ライセンス アクション
05_Mori.pdf 05_Mori.pdf (4.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-09-04
タイトル
タイトル Therapeutic effect of adipose-derived regenerative cells on bladder function in rats with underactive bladder
著者 Mori, Aya

× Mori, Aya

WEKO 101020

Mori, Aya

Search repository
Matsukawa, Yoshihisa

× Matsukawa, Yoshihisa

WEKO 101021

Matsukawa, Yoshihisa

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Funahashi, Yasuhito

× Funahashi, Yasuhito

WEKO 101022

Funahashi, Yasuhito

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Majima, Tsuyoshi

× Majima, Tsuyoshi

WEKO 101023

Majima, Tsuyoshi

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Takai, Shun

× Takai, Shun

WEKO 101024

Takai, Shun

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Yamamoto, Tokunori

× Yamamoto, Tokunori

WEKO 101025

Yamamoto, Tokunori

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Gotoh, Momokazu

× Gotoh, Momokazu

WEKO 101026

Gotoh, Momokazu

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キーワード
主題Scheme Other
主題 underactive bladder
キーワード
主題Scheme Other
主題 adipose-derived regenerative cells
キーワード
主題Scheme Other
主題 over-distention
キーワード
主題Scheme Other
主題 bladder function
キーワード
主題Scheme Other
主題 detrusor underactivity
抄録
内容記述 We examined the effect of adipose-derived regenerative cells (ADRC) on bladder functions in a rat model of detrusor underactivity (DU) induced by bladder over-distention.
Adult female Sprague Dawley rats were divided into 3 groups: sham group (control); over-distention group; and over-distention with ADRC treatment group. Bladder was over-distended with saline (2.7mL) on day 1, 8, 15 and 22 of the study. ADRCs, which were harvested from male F344 rats, expanded via culture, were injected into the bladder wall at day 15. Cystometry and in vitro organ bath functional studies were performed on day 28. Moreover, histological assessment of the bladder was performed.
In cystometry, significant prolongation of the inter-contraction interval (ICI) and decrease of voiding ef-ficiency (VE) were observed in the over-distention group, compared to that in the control group. Significant improvement in ICI and VE was seen in the ADRC treatment group in comparison with the over-distention group. The over-distention group showed significantly weaker bladder contractile responses to carbachol and electrical field stimulation than the control group, while bladder contractile responses were significantly stronger in the ADRC treatment group than that in the over-distention group. The over-distention group showed substantial fibrosis of the bladder compared to the control group, whereas bladder fibrosis was alleviated in the ADRC treatment group.
In conclusion, the injection of ADRC into bladder wall improved bladder dysfunction and histological changes induced by bladder over-distention. ADRCs-based regenerative therapy could be novel treatment for DU.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.3.425
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 3, p. 425-435, 発行日 2020-08
著者版フラグ
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