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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(3)

Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells

https://doi.org/10.18999/nagjms.82.3.509
https://doi.org/10.18999/nagjms.82.3.509
0b4c652a-174f-4a57-b060-92c8c5422bc5
名前 / ファイル ライセンス アクション
13_Ichimaru.pdf 13_Ichimaru.pdf (8.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-09-04
タイトル
タイトル Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells
著者 Ichimaru, Yoshimi

× Ichimaru, Yoshimi

WEKO 101072

Ichimaru, Yoshimi

Search repository
Kanaeda, Natsuki

× Kanaeda, Natsuki

WEKO 101073

Kanaeda, Natsuki

Search repository
Tominaga, Sarah

× Tominaga, Sarah

WEKO 101074

Tominaga, Sarah

Search repository
Suzui, Masumi

× Suzui, Masumi

WEKO 101075

Suzui, Masumi

Search repository
Maeda, Tohru

× Maeda, Tohru

WEKO 101076

Maeda, Tohru

Search repository
Fujii, Hirohisa

× Fujii, Hirohisa

WEKO 101077

Fujii, Hirohisa

Search repository
Nakao, Makoto

× Nakao, Makoto

WEKO 101078

Nakao, Makoto

Search repository
Yoshioka, Hiroki

× Yoshioka, Hiroki

WEKO 101079

Yoshioka, Hiroki

Search repository
キーワード
主題Scheme Other
主題 Sasa veitchii
キーワード
主題Scheme Other
主題 cyclin D1
キーワード
主題Scheme Other
主題 breast cancer
キーワード
主題Scheme Other
主題 sodium copper chlorophyllin
抄録
内容記述 Sasa veitchii and other Sasa species are traditional medicinal herbs belonging to a group of Japanese bamboos collectively called Kumazasa, and these species possess the potential for a wide variety of uses. The present study aimed to elucidate the anticancer mechanisms exerted by S. veitchii extract (SE) against a human breast cancer cell line, MCF-7 cells. Freeze-dried Sunchlon® was used as the SE, and cell proliferation activity was measured using the [3H]-thymidine incorporation assay. Induction of apoptosis was assessed via Annexin V and caspase-3 fluorescent staining, the induction of necrosis was measured via propidium iodide staining, and cell cycle-related protein expression was determined using western blot-ting. The IC50 value of the SE was 7.7 μg/mL in MCF-7 cells. Although the primary active ingredient in Sunchlon® is sodium copper chlorophyllin (0.25%), the present results indicated that ingredients other than SCC exert anti-cancer activities (the IC50 value of SCC was 715 μg/mL), and late apoptosis or necrosis was induced in an SE dose-dependent manner. The expression levels of cyclin D1 and Cdk6 were decreased after SE treatment, and there was no change in the Cdk1/2 expression levels. Additionally, the expression of the necrosis-related cell death indicators RIP1 and RIP3 was increased in response to high-dose SE treatments, and this was indicative of cells preparing for programmed cell death. SE induces cell death in MCF-7 cells via the inhibition of cyclin D1 expression at low concentrations, and this extract induces programmed necrosis (necroptosis) by potentiating RIP1/RIP3 expression.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.3.509
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/823.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 3, p. 509-518, 発行日 2020-08
著者版フラグ
値 publisher
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