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Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity
http://hdl.handle.net/2237/00032723
http://hdl.handle.net/2237/00032723a589d31f-2869-4d1e-8392-654957a169d9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
revised_manuscript (648.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-13 | |||||
| タイトル | ||||||
| タイトル | Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity | |||||
| 言語 | en | |||||
| 著者 |
Fuse, Shinichiro
× Fuse, Shinichiro× Moriya, Wataru× Sato, Shinichi× Nakamura, Hiroyuki |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Photodynamic therapy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Organic dye | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sensitizer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Singlet oxygen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Endocytosis | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Photodynamic therapy (PDT) is a non-invasive, selective, and cost-effective cancer therapy. We previously reported that thiophene-based organic D-π-A sensitizers consist of an electron-donating (D) moiety, a π-conjugated bridge (π) moiety, and an electron-accepting (A) moiety, and are readily accessible and stable templates for photosensitizers that could be used in PDT. In addition, acrylic acid acceptor-containing photosensitizers exert a high level of phototoxicity. This study was an investigation into 1) the possibility of increasing phototoxicity by introducing another carboxyl group or by replacing a carboxyl group with a pyridinium group, and 2) the importance of an alkene in the acrylic acid acceptor for phototoxicity. A review of the design, synthesis, and evaluation of sensitizers revealed that neither dicarboxylic acid nor pyridinium photosensitizers enhance phototoxicity. An evaluation of a photosensitizer without an alkene in the acrylic acid moiety revealed that the alkene was not indispensable in the pursuit of phototoxicity. The obtained results provided new insight into the design of ideal D-π-A photosensitizers for PDT. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2022-07-01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bmc.2020.115558 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0968-0896 | |||||
| 書誌情報 |
en : Bioorganic & Medicinal Chemistry 巻 28, 号 13, p. 115558, 発行日 2020-07 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
