ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "60c4bd96-0170-493d-9e00-191a67a352d7"}, "_deposit": {"id": "30538", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "30538"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00030538"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "13", "bibliographicPageStart": "115558", "bibliographicVolumeNumber": "28", "bibliographic_titles": [{"bibliographic_title": "Bioorganic \u0026 Medicinal Chemistry"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Photodynamic therapy (PDT) is a non-invasive, selective, and cost-effective cancer therapy. We previously reported that thiophene-based organic D-\u03c0-A sensitizers consist of an electron-donating (D) moiety, a \u03c0-conjugated bridge (\u03c0) moiety, and an electron-accepting (A) moiety, and are readily accessible and stable templates for photosensitizers that could be used in PDT. In addition, acrylic acid acceptor-containing photosensitizers exert a high level of phototoxicity. This study was an investigation into 1) the possibility of increasing phototoxicity by introducing another carboxyl group or by replacing a carboxyl group with a pyridinium group, and 2) the importance of an alkene in the acrylic acid acceptor for phototoxicity. A review of the design, synthesis, and evaluation of sensitizers revealed that neither dicarboxylic acid nor pyridinium photosensitizers enhance phototoxicity. An evaluation of a photosensitizer without an alkene in the acrylic acid moiety revealed that the alkene was not indispensable in the pursuit of phototoxicity. The obtained results provided new insight into the design of ideal D-\u03c0-A photosensitizers for PDT.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2022-07-01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.bmc.2020.115558", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0968-0896", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fuse, Shinichiro"}], "nameIdentifiers": [{"nameIdentifier": "101639", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moriya, Wataru"}], "nameIdentifiers": [{"nameIdentifier": "101640", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Shinichi"}], "nameIdentifiers": [{"nameIdentifier": "101641", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "101642", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-07-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "revised_manuscript.pdf", "filesize": [{"value": "648.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 648700.0, "url": {"label": "revised_manuscript", "url": "https://nagoya.repo.nii.ac.jp/record/30538/files/revised_manuscript.pdf"}, "version_id": "dd728c45-ceae-43d5-90a7-878c415dc1ed"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Photodynamic therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Organic dye", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Sensitizer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Singlet oxygen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Endocytosis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Investigation into the influence of an acrylic acid acceptor in organic D-\u03c0-A sensitizers against phototoxicity", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Investigation into the influence of an acrylic acid acceptor in organic D-\u03c0-A sensitizers against phototoxicity"}]}, "item_type_id": "10", "owner": "1", "path": ["1903/1904/1905"], "permalink_uri": "http://hdl.handle.net/2237/00032723", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2020-10-13"}, "publish_date": "2020-10-13", "publish_status": "0", "recid": "30538", "relation": {}, "relation_version_is_last": true, "title": ["Investigation into the influence of an acrylic acid acceptor in organic D-\u03c0-A sensitizers against phototoxicity"], "weko_shared_id": null}
  1. D400 創薬科学研究科
  2. D400a 雑誌掲載論文
  3. 学術雑誌

Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity

http://hdl.handle.net/2237/00032723
a589d31f-2869-4d1e-8392-654957a169d9
名前 / ファイル ライセンス アクション
revised_manuscript.pdf revised_manuscript (648.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-10-13
タイトル
タイトル Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity
著者 Fuse, Shinichiro

× Fuse, Shinichiro

WEKO 101639

Fuse, Shinichiro

Search repository
Moriya, Wataru

× Moriya, Wataru

WEKO 101640

Moriya, Wataru

Search repository
Sato, Shinichi

× Sato, Shinichi

WEKO 101641

Sato, Shinichi

Search repository
Nakamura, Hiroyuki

× Nakamura, Hiroyuki

WEKO 101642

Nakamura, Hiroyuki

Search repository
権利
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Photodynamic therapy
キーワード
主題Scheme Other
主題 Organic dye
キーワード
主題Scheme Other
主題 Sensitizer
キーワード
主題Scheme Other
主題 Singlet oxygen
キーワード
主題Scheme Other
主題 Endocytosis
抄録
内容記述 Photodynamic therapy (PDT) is a non-invasive, selective, and cost-effective cancer therapy. We previously reported that thiophene-based organic D-π-A sensitizers consist of an electron-donating (D) moiety, a π-conjugated bridge (π) moiety, and an electron-accepting (A) moiety, and are readily accessible and stable templates for photosensitizers that could be used in PDT. In addition, acrylic acid acceptor-containing photosensitizers exert a high level of phototoxicity. This study was an investigation into 1) the possibility of increasing phototoxicity by introducing another carboxyl group or by replacing a carboxyl group with a pyridinium group, and 2) the importance of an alkene in the acrylic acid acceptor for phototoxicity. A review of the design, synthesis, and evaluation of sensitizers revealed that neither dicarboxylic acid nor pyridinium photosensitizers enhance phototoxicity. An evaluation of a photosensitizer without an alkene in the acrylic acid moiety revealed that the alkene was not indispensable in the pursuit of phototoxicity. The obtained results provided new insight into the design of ideal D-π-A photosensitizers for PDT.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2022-07-01
内容記述タイプ Other
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bmc.2020.115558
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0968-0896
書誌情報 Bioorganic & Medicinal Chemistry

巻 28, 号 13, p. 115558, 発行日 2020-07
著者版フラグ
値 author
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:46:49.759271
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio