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  1. H220 細胞生理学研究センター
  2. H220a 雑誌掲載論文
  3. 学術雑誌

Structural insights into gap junction channels boosted by cryo-EM

http://hdl.handle.net/2237/00033206
http://hdl.handle.net/2237/00033206
1b5a9921-42dd-42e5-b918-fcecce41157d
名前 / ファイル ライセンス アクション
Oshima_2020COSBT.pdf Oshima_2020COSBT (348.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-12-16
タイトル
タイトル Structural insights into gap junction channels boosted by cryo-EM
言語 en
著者 Oshima, Atsunori

× Oshima, Atsunori

WEKO 102588

en Oshima, Atsunori

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
抄録
内容記述 Regulating intercellular communication is essential for multicellular organisms. Gap junction channels are the major components mediating this function, but the molecular mechanisms underlying their opening and closing remain unclear. Single-particle cryo-electron microscopy (cryo-EM) is a powerful tool for investigating high-resolution protein structures that are difficult to crystallize, such as gap junction channels. Membrane protein structures are often determined in a detergent solubilized form, but lipid bilayers provide a near native environment for structural analysis. This review focuses on recent reports of gap junction channel structures visualized by cryo-EM. An overview of the differences observed in gap junction channel structures in the presence and absence of lipids is described, which may contribute to elucidating the regulation mechanisms of gap junction channel function.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021-08-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.sbi.2020.03.008
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0959-440X
書誌情報 en : Current Opinion in Structural Biology

巻 63, p. 42-48, 発行日 2020-08
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