{"_buckets": {"deposit": "3b0870e0-2736-48ab-a88c-40a2ffb2e952"}, "_deposit": {"id": "31053", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "31053"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00031053", "sets": []}, "author_link": ["102700", "102701", "102702", "102703", "102704", "102705", "102706", "102707", "102708", "102709", "102710", "102711", "102712", "102713"], "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-02-27", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "35", "bibliographicPageEnd": "5794", "bibliographicPageStart": "5782", "bibliographicVolumeNumber": "39", "bibliographic_titles": [{"bibliographic_title": "Oncogene", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non\u2013PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that allow non\u2013PB-ATLs to proliferate and invade compared with PB-ATLs. Protein array analysis revealed hepatocyte growth factor (HGF) and C-C motif chemokine 2 (CCL2) were significantly upregulated in non\u2013PB-ATLs compared with PB-ATLs. The HGF membrane receptor, c-Met, was expressed in PB-ATL and non\u2013PB-ATL cell lines, but CCR2, a CCL2 receptor, was not. Immunohistochemical analysis in clinical ATLs revealed high HGF expression in LNs, pharynx, bone marrow, and tonsils. The HGF/c-Met signaling pathway was active downstream in non\u2013PB-ATLs. Downregulation of HGF/c-Met by siRNA or chemical inhibitors decreased in vitro and in vivo proliferation and invasion by non\u2013PB-ATLs. Treatment with bromodomain and extra-terminal motif inhibitor suppressed HGF expression and decreased levels of histone H3 lysine 27 acetylation (H3K27Ac) and bromodomain-containing protein 4 (BRD4) binding promoter and enhancer regions, suppressing non\u2013PB-ATL cellular growth. Our data indicate H3K27Ac/BRD4 epigenetics regulates the HGF/c-MET pathway in ATLs; targeting this pathway may improve treatment of aggressive non\u2013PB-ATLs.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2021/02/27", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer Nature", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/s41388-020-01393-x", "subitem_relation_type_select": "DOI"}}]}, "item_10_select_15": {"attribute_name": 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[{"creatorName": "Shinjo, Keiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102701", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Miho", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102702", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsushima, Keisuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102703", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mase, Shoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102704", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masaki, Ayako", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102705", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Asahi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102706", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ri, Masaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102707", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kusumoto, Shigeru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102708", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu, Hirokazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102709", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishida, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102710", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inagaki, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102711", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iida, Shinsuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "102712", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo, Yutaka", 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"subitem_subject_scheme": "Other"}, {"subitem_subject": "Histone post-translational modifications", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Leukaemia", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00033234", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-12-23"}, "publish_date": "2020-12-23", "publish_status": "0", "recid": "31053", "relation": {}, "relation_version_is_last": true, "title": ["Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma"], "weko_shared_id": -1}