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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma

http://hdl.handle.net/2237/00033234
http://hdl.handle.net/2237/00033234
194f92de-6724-492e-b3e8-cb9851b56a66
名前 / ファイル ライセンス アクション
NAGOYARepository_Kondo_Yutaka.pdf NAGOYARepository_Kondo_Yutaka (1.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-12-23
タイトル
タイトル Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma
言語 en
著者 Totani, Haruhito

× Totani, Haruhito

WEKO 102700

en Totani, Haruhito

Search repository
Shinjo, Keiko

× Shinjo, Keiko

WEKO 102701

en Shinjo, Keiko

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Suzuki, Miho

× Suzuki, Miho

WEKO 102702

en Suzuki, Miho

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Katsushima, Keisuke

× Katsushima, Keisuke

WEKO 102703

en Katsushima, Keisuke

Search repository
Mase, Shoko

× Mase, Shoko

WEKO 102704

en Mase, Shoko

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Masaki, Ayako

× Masaki, Ayako

WEKO 102705

en Masaki, Ayako

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Ito, Asahi

× Ito, Asahi

WEKO 102706

en Ito, Asahi

Search repository
Ri, Masaki

× Ri, Masaki

WEKO 102707

en Ri, Masaki

Search repository
Kusumoto, Shigeru

× Kusumoto, Shigeru

WEKO 102708

en Kusumoto, Shigeru

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Komatsu, Hirokazu

× Komatsu, Hirokazu

WEKO 102709

en Komatsu, Hirokazu

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Ishida, Takashi

× Ishida, Takashi

WEKO 102710

en Ishida, Takashi

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Inagaki, Hiroshi

× Inagaki, Hiroshi

WEKO 102711

en Inagaki, Hiroshi

Search repository
Iida, Shinsuke

× Iida, Shinsuke

WEKO 102712

en Iida, Shinsuke

Search repository
Kondo, Yutaka

× Kondo, Yutaka

WEKO 102713

en Kondo, Yutaka

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Cytokines
キーワード
主題Scheme Other
主題 Histone post-translational modifications
キーワード
主題Scheme Other
主題 Leukaemia
抄録
内容記述 Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non–PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that allow non–PB-ATLs to proliferate and invade compared with PB-ATLs. Protein array analysis revealed hepatocyte growth factor (HGF) and C-C motif chemokine 2 (CCL2) were significantly upregulated in non–PB-ATLs compared with PB-ATLs. The HGF membrane receptor, c-Met, was expressed in PB-ATL and non–PB-ATL cell lines, but CCR2, a CCL2 receptor, was not. Immunohistochemical analysis in clinical ATLs revealed high HGF expression in LNs, pharynx, bone marrow, and tonsils. The HGF/c-Met signaling pathway was active downstream in non–PB-ATLs. Downregulation of HGF/c-Met by siRNA or chemical inhibitors decreased in vitro and in vivo proliferation and invasion by non–PB-ATLs. Treatment with bromodomain and extra-terminal motif inhibitor suppressed HGF expression and decreased levels of histone H3 lysine 27 acetylation (H3K27Ac) and bromodomain-containing protein 4 (BRD4) binding promoter and enhancer regions, suppressing non–PB-ATL cellular growth. Our data indicate H3K27Ac/BRD4 epigenetics regulates the HGF/c-MET pathway in ATLs; targeting this pathway may improve treatment of aggressive non–PB-ATLs.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2021/02/27
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Springer Nature
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41388-020-01393-x
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0950-9232
書誌情報 en : Oncogene

巻 39, 号 35, p. 5782-5794, 発行日 2020-02-27
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