{"_buckets": {"deposit": "3b0870e0-2736-48ab-a88c-40a2ffb2e952"}, "_deposit": {"id": "31053", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "31053"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00031053"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-02-27", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "35", "bibliographicPageEnd": "5794", "bibliographicPageStart": "5782", "bibliographicVolumeNumber": "39", "bibliographic_titles": [{"bibliographic_title": "Oncogene"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non\u2013PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that allow non\u2013PB-ATLs to proliferate and invade compared with PB-ATLs. Protein array analysis revealed hepatocyte growth factor (HGF) and C-C motif chemokine 2 (CCL2) were significantly upregulated in non\u2013PB-ATLs compared with PB-ATLs. The HGF membrane receptor, c-Met, was expressed in PB-ATL and non\u2013PB-ATL cell lines, but CCR2, a CCL2 receptor, was not. Immunohistochemical analysis in clinical ATLs revealed high HGF expression in LNs, pharynx, bone marrow, and tonsils. The HGF/c-Met signaling pathway was active downstream in non\u2013PB-ATLs. Downregulation of HGF/c-Met by siRNA or chemical inhibitors decreased in vitro and in vivo proliferation and invasion by non\u2013PB-ATLs. Treatment with bromodomain and extra-terminal motif inhibitor suppressed HGF expression and decreased levels of histone H3 lysine 27 acetylation (H3K27Ac) and bromodomain-containing protein 4 (BRD4) binding promoter and enhancer regions, suppressing non\u2013PB-ATL cellular growth. Our data indicate H3K27Ac/BRD4 epigenetics regulates the HGF/c-MET pathway in ATLs; targeting this pathway may improve treatment of aggressive non\u2013PB-ATLs.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2021/02/27", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer Nature"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/s41388-020-01393-x", "subitem_relation_type_select": "DOI"}}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0950-9232", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Totani, Haruhito"}], "nameIdentifiers": [{"nameIdentifier": "102700", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinjo, Keiko"}], "nameIdentifiers": [{"nameIdentifier": "102701", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Miho"}], "nameIdentifiers": [{"nameIdentifier": "102702", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsushima, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "102703", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mase, Shoko"}], "nameIdentifiers": [{"nameIdentifier": "102704", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masaki, Ayako"}], "nameIdentifiers": [{"nameIdentifier": 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"Cytokines", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Histone post-translational modifications", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Leukaemia", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00033234", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2020-12-23"}, "publish_date": "2020-12-23", "publish_status": "0", "recid": "31053", "relation": {}, "relation_version_is_last": true, "title": ["Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma"], "weko_shared_id": null}