{"_buckets": {"deposit": "72cc8fc7-8392-463e-b0fa-d30fdbeb9eff"}, "_deposit": {"id": "3942", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3942"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00003942"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-2", "bibliographicPageEnd": "8", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "65", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Abnormal contraction of vascular smooth muscle contributes to a variety of diseases such as hypertension and vasospasm in coronary and cerebral arteries. An increment in a cytoplasmic Ca2+ concentration is the key event in smooth muscle contraction. However, smooth muscle contraction is modified upon the stimulation by agonists as well as in some pathophysiological situations in Ca2+-independent mechanism.  The molecular mechanism underlying this modulation was not elucidated. Recent studies have shown the important role of small GTPase Rho and its effector, Rho-associated kinase (Rho-kinase)/ROK/ROCK in Ca2+-independent regulation of smooth muscle contraction. The Rho/Rho-kinase pathway modulates the phosphorylation level of myosin light chain (MLC) of myosin II, mainly through the inhibition of myosin phosphatase, and contributes to the agonist-induced Ca2+-sensitization in smooth muscle contraction. The Rho/Rho-kinase pathway is involved in the pathogenesis of hypertension, vasospasm and arteriosclerosis, and is a potent target of new therapies for these diseases.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/5374"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.65.1-2.1", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawano, Yoji"}], "nameIdentifiers": [{"nameIdentifier": "10069", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshimura, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "10070", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaibuchi, Kozo"}], "nameIdentifiers": [{"nameIdentifier": "10071", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "nj6511.pdf", "filesize": [{"value": "80.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 80100.0, "url": {"label": "nj6511.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/3942/files/nj6511.pdf"}, "version_id": "5fdc7d60-e8cd-4211-9932-e294bedb7c62"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Rho", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rho-kinase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myosin light chain (MLC)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myosin phosphatase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myosin-binding subunit (MBS)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ca2+-sensitization", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Smooth muscle contraction by small GTPase Rho", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Smooth muscle contraction by small GTPase Rho"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/515"], "permalink_uri": "https://doi.org/10.18999/nagjms.65.1-2.1", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2006-02-08"}, "publish_date": "2006-02-08", "publish_status": "0", "recid": "3942", "relation": {}, "relation_version_is_last": true, "title": ["Smooth muscle contraction by small GTPase Rho"], "weko_shared_id": null}