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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 65(1-2)

Smooth muscle contraction by small GTPase Rho

https://doi.org/10.18999/nagjms.65.1-2.1
https://doi.org/10.18999/nagjms.65.1-2.1
71885bcd-e8eb-4d8e-9b17-076b4d89b2c4
名前 / ファイル ライセンス アクション
nj6511.pdf nj6511.pdf (80.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-08
タイトル
タイトル Smooth muscle contraction by small GTPase Rho
著者 Kawano, Yoji

× Kawano, Yoji

WEKO 10069

Kawano, Yoji

Search repository
Yoshimura, Takeshi

× Yoshimura, Takeshi

WEKO 10070

Yoshimura, Takeshi

Search repository
Kaibuchi, Kozo

× Kaibuchi, Kozo

WEKO 10071

Kaibuchi, Kozo

Search repository
キーワード
主題Scheme Other
主題 Rho
キーワード
主題Scheme Other
主題 Rho-kinase
キーワード
主題Scheme Other
主題 myosin light chain (MLC)
キーワード
主題Scheme Other
主題 myosin phosphatase
キーワード
主題Scheme Other
主題 myosin-binding subunit (MBS)
キーワード
主題Scheme Other
主題 Ca2+-sensitization
抄録
内容記述 Abnormal contraction of vascular smooth muscle contributes to a variety of diseases such as hypertension and vasospasm in coronary and cerebral arteries. An increment in a cytoplasmic Ca2+ concentration is the key event in smooth muscle contraction. However, smooth muscle contraction is modified upon the stimulation by agonists as well as in some pathophysiological situations in Ca2+-independent mechanism. The molecular mechanism underlying this modulation was not elucidated. Recent studies have shown the important role of small GTPase Rho and its effector, Rho-associated kinase (Rho-kinase)/ROK/ROCK in Ca2+-independent regulation of smooth muscle contraction. The Rho/Rho-kinase pathway modulates the phosphorylation level of myosin light chain (MLC) of myosin II, mainly through the inhibition of myosin phosphatase, and contributes to the agonist-induced Ca2+-sensitization in smooth muscle contraction. The Rho/Rho-kinase pathway is involved in the pathogenesis of hypertension, vasospasm and arteriosclerosis, and is a potent target of new therapies for these diseases.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.65.1-2.1
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 65, 号 1-2, p. 1-8, 発行日 2002-05
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5374
識別子タイプ HDL
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