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Smooth muscle contraction by small GTPase Rho
https://doi.org/10.18999/nagjms.65.1-2.1
https://doi.org/10.18999/nagjms.65.1-2.171885bcd-e8eb-4d8e-9b17-076b4d89b2c4
名前 / ファイル | ライセンス | アクション |
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nj6511.pdf (80.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-02-08 | |||||
タイトル | ||||||
タイトル | Smooth muscle contraction by small GTPase Rho | |||||
言語 | en | |||||
著者 |
Kawano, Yoji
× Kawano, Yoji× Yoshimura, Takeshi× Kaibuchi, Kozo |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rho | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rho-kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myosin light chain (MLC) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myosin phosphatase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myosin-binding subunit (MBS) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ca2+-sensitization | |||||
抄録 | ||||||
内容記述 | Abnormal contraction of vascular smooth muscle contributes to a variety of diseases such as hypertension and vasospasm in coronary and cerebral arteries. An increment in a cytoplasmic Ca2+ concentration is the key event in smooth muscle contraction. However, smooth muscle contraction is modified upon the stimulation by agonists as well as in some pathophysiological situations in Ca2+-independent mechanism. The molecular mechanism underlying this modulation was not elucidated. Recent studies have shown the important role of small GTPase Rho and its effector, Rho-associated kinase (Rho-kinase)/ROK/ROCK in Ca2+-independent regulation of smooth muscle contraction. The Rho/Rho-kinase pathway modulates the phosphorylation level of myosin light chain (MLC) of myosin II, mainly through the inhibition of myosin phosphatase, and contributes to the agonist-induced Ca2+-sensitization in smooth muscle contraction. The Rho/Rho-kinase pathway is involved in the pathogenesis of hypertension, vasospasm and arteriosclerosis, and is a potent target of new therapies for these diseases. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.65.1-2.1 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 65, 号 1-2, p. 1-8, 発行日 2002-05 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/5374 | |||||
識別子タイプ | HDL |