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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 67(1-2)

Incorporation, remodeling and re-expression of exogenous gangliosides in human cancer cell lines in vitro and in vivo

https://doi.org/10.18999/nagjms.67.1-2.35
https://doi.org/10.18999/nagjms.67.1-2.35
91371c3f-e9a1-4b12-8609-d31b623dd11d
名前 / ファイル ライセンス アクション
p35_44.pdf p35_44.pdf (235.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-10
タイトル
タイトル Incorporation, remodeling and re-expression of exogenous gangliosides in human cancer cell lines in vitro and in vivo
言語 en
著者 Nishio, Masashi

× Nishio, Masashi

WEKO 10166

en Nishio, Masashi

Search repository
Furukawa, Koichi

× Furukawa, Koichi

WEKO 10167

en Furukawa, Koichi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Ganglioside
キーワード
主題Scheme Other
主題 NeuG
キーワード
主題Scheme Other
主題 Sialic acid
キーワード
主題Scheme Other
主題 Recycle
キーワード
主題Scheme Other
主題 Glycosyltransferase
キーワード
主題Scheme Other
主題 Astrocytoma
抄録
内容記述 Human neuroblastomas and gliomas express high levels of GD2 ganglioside. Mechanisms for the re-expression of GD2 after the incorporation of an exogenous precursor structure were analyzed using a human heterophilic monoclonal antibody (mAb) together with mouse anti-GD3 and mouse anti-GD2 mAbs. First, mouse anti-GD2 mAb 220-51 was generated and its reactivity was confirmed to be almost identical with that of the well-known mAb 3F8 antibody. As reported previously for GD3 variants, new ganglioside antigens reactive with human mAb 32-27 were analyzed by culturing an astrocytoma cell line AS in the presence of NeuGc-GM3. Analysis of the extracted gangliosides from AS thus cultured revealed a new component detected with mAb 32-27, migrating similarly to GD2. Incorporated NeuGc-GM3 seemed to be converted to NeuAc-NeuGc-type GD3, and then to NeuAc-NeuGc-type GD2 with α2,8-sialyltransferase and β1,4-GalNAc transferase, respectively. In addition, AS was inoculated into nude mice, and glycolipids were extracted from generated tumors. Analysis of the ganglioside components using mAbs indicated that NeuAc-NeuGc-type GD2 was generated in the xenogeneic tumors by incorporating NeuGc-GM3 from mouse blood. These results indicated the presence of a pathway for utilization of exogenous gangliosides for remodeling and re-expression in vivo.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.67.1-2.35
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 67, 号 1-2, p. 35-44, 発行日 2004-05
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5402
識別子タイプ HDL
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