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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Calcium oscillation linked to pacemaking of interstitial cells of Cajal;Requirement of calcium influx and localisation of TRP4 in caveolae

http://hdl.handle.net/2237/7447
78672df5-d126-404d-9b00-4a4f287db265
名前 / ファイル ライセンス アクション
M2-01728a.pdf M2-01728a.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-03-08
タイトル
タイトル Calcium oscillation linked to pacemaking of interstitial cells of Cajal;Requirement of calcium influx and localisation of TRP4 in caveolae
著者 Torihashi, Shigeko

× Torihashi, Shigeko

WEKO 15488

Torihashi, Shigeko

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Fujimoto, Toyoshi

× Fujimoto, Toyoshi

WEKO 15489

Fujimoto, Toyoshi

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Trost, Claudia

× Trost, Claudia

WEKO 15490

Trost, Claudia

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Nakayama, Shinsuke

× Nakayama, Shinsuke

WEKO 15491

Nakayama, Shinsuke

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鳥橋, 茂子

× 鳥橋, 茂子

WEKO 15492

鳥橋, 茂子

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抄録
内容記述 Interstitial cells of Cajal (ICC) are considered to be pacemaker cells in gastrointestinal tracts. ICC generate rhythmical electronic activity as slow waves, which is dihydropyridine-insensitive,
and drive spontaneous contraction of smooth muscles. Although cytosolic Ca2+ has been assumed to play a key role in pacemaking, Ca2+ movements in ICC have not yet been examined in detail. In the present study, using cultured cell clusters isolated from the mouse small intestine, we demonstrated Ca2+
oscillations in ICC. Fluo4 was loaded to the cell cluster, the relative amount of cytosolic Ca2+ was recorded, and ICC were identified by c-Kit immunoreactivity. We specifically detected Ca2+ oscillation in ICC in the presence of dihydropyridine, which abolishes Ca2+ oscillation in smooth muscles. The oscillation was coupled to the electrical activity corresponding to slow waves and depended on Ca2+ influx through a non-selective
cation channel, which was SK&F 96365-sensitive
and store-operated.
We further demonstrated the presence of transient receptor potential-like
channel 4 (TRP4) in caveolae of ICC.
Taken together, the results infer that the Ca2+ oscillation in ICC is intimately linked to the pacemaker function and depends on Ca2+ influx mediated by TRP4.
内容記述タイプ Abstract
出版者
出版者 The American Society for Biochemistry and Molecular Biology
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1074/jbc.M201728200
ISSN
収録物識別子タイプ ISSN
収録物識別子 0021-9258
書誌情報 Journal of Biological Chemistry

巻 277, 号 21, p. 19191-19197, 発行日 2002-05
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7447
識別子タイプ HDL
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