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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 47

Restitution Kinetics of Ventricular Action Potential Duration In the Human Heart

https://doi.org/10.18999/envm.47.66
https://doi.org/10.18999/envm.47.66
a91d7fc8-62bc-4360-94eb-22788922860c
名前 / ファイル ライセンス アクション
66-68.pdf 66-68.pdf (284.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-04-06
タイトル
タイトル Restitution Kinetics of Ventricular Action Potential Duration In the Human Heart
言語 en
著者 Yamazaki, Masatoshi

× Yamazaki, Masatoshi

WEKO 15980

en Yamazaki, Masatoshi

Search repository
Honjo, Haruo

× Honjo, Haruo

WEKO 15981

en Honjo, Haruo

Search repository
Osaka, Toshiyuki

× Osaka, Toshiyuki

WEKO 15982

en Osaka, Toshiyuki

Search repository
Yokoyama, Eriko

× Yokoyama, Eriko

WEKO 15983

en Yokoyama, Eriko

Search repository
Ito, Atsushi

× Ito, Atsushi

WEKO 15984

en Ito, Atsushi

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Kodama, Itsuo

× Kodama, Itsuo

WEKO 15985

en Kodama, Itsuo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 restitution
キーワード
主題Scheme Other
主題 action potential duration
キーワード
主題Scheme Other
主題 ventricular fibrillation
抄録
内容記述 Recent animal experiments and computer modeling have suggested that cardiac tissues showing steep slope (>1) of action potential duration (APD) restitution would provide a dynamic instability of refractoriness causing a wave break, which is required for the genesis of polymorphic ventricular tachycardia or ventricular fibrillation. However, much remains to be clarified as to the APD restitution kinetics in the normal ventricular myocardium of humans. Monophasic action potentials were recorded from the right ventricular apex and outflow tract in five patients who had no ventricular tachyarrhythmias or structural heart disease. APD restitution kinetics was estimated by a standard S1-S2 protocol. The APD restitution curve was constructed by plotting APD_<90> for each premature stimulus (S2) as a parameter of the preceding diastolic interval. The average values of slope_<max> of APD_<90> for each premature stimulus (S2) as a parameter of the preceding diastolic interval. The average values of slope_<max> of APD restitution curve were 0.44±0.09 in RVA and 0.49±0.10 in RVOT. The slope_<max> did not exceed 1.0 at any recording sites. These results suggest that normal ventricular muscle in humans have minimal repolarization instability initiating wave break.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.47.66
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0287-0517
書誌情報 en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 47, p. 66-68, 発行日 2003-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7599
識別子タイプ HDL
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