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Computer Simulation Analysis of Shock Intensity - and Phase - Dependence of High-Intensity DC Stimulation Aftereffects on Action Potential of Ventricular Muscle
https://doi.org/10.18999/envm.47.69
623b7a38-e42c-4c85-a744-c5106e244ea7
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-04-06 | |||||
タイトル | ||||||
タイトル | Computer Simulation Analysis of Shock Intensity - and Phase - Dependence of High-Intensity DC Stimulation Aftereffects on Action Potential of Ventricular Muscle | |||||
著者 |
Ohuchi, Katsuhiro
× Ohuchi, Katsuhiro× Fukui, Yasuhiro× Sakuma, Ichiro× Shibata, Nitaro× Honjo, Haruo× Takatani, Setsuo× Kodama, Itsuo |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | defibrillation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | electroporation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | computer simulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | action potentials | |||||
抄録 | ||||||
内容記述 | The shock intensity-and phase-dependence of high-intensity DC stimulation aftereffects was studied by using Luo-Rudy’s dynamic action potential model. Shock-induced transient rupture (electroporation) of the cell membrane was represented by incorporation of non-selective ionic pores. Application of DC shocks during the plateau phase caused a prolongation of the action potential. Diastolic phase shocks resulted in an activation of action potential with similar delay in repolarization. Oscillatory membrane potentials and single or multiple spontaneous excitations were induced by DC shocks with intermediate intensity and these were accompanied by activation of L-type calcium current during the plateau phase. These results are consistent with observations in animal experiments. The Luo-Rudy’s dynamic action potential model with reversible electroporation-mediated pores may provide useful tools to investigate membrane potential changes and underlying ionic mechanisms following electrical shocks. | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.47.69 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0287-0517 | |||||
書誌情報 |
Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 47, p. 69-71, 発行日 2003-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/7600 | |||||
識別子タイプ | HDL |