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腸管平滑筋運動におけるカハールの介在細胞と壁内神経 (特集. Neurogastroenterologyの幕開け)
http://hdl.handle.net/2237/7893
http://hdl.handle.net/2237/78932178eb86-de8b-458f-a8e0-96b3a6f0be2f
名前 / ファイル | ライセンス | アクション |
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rin_sho_naika_18_1371.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-05-25 | |||||
タイトル | ||||||
タイトル | 腸管平滑筋運動におけるカハールの介在細胞と壁内神経 (特集. Neurogastroenterologyの幕開け) | |||||
言語 | ja | |||||
その他のタイトル | ||||||
その他のタイトル | Interstitial Cells of Cajal and Enteric Neurons in the Gastrointestinal Tract | |||||
言語 | en | |||||
著者 |
鳥橋, 茂子
× 鳥橋, 茂子× Torihashi, Shigeko |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | ja | |||||
権利情報 | 本論文は日本メディカルセンターの許可を得て電子ファイル化したものである。 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | カハールの介在細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interstitial cells of Cajal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ペースメーカー | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pacemaker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 腸管神経 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enteric nerve | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 緩徐波 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | slow wave | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 平滑筋 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | smooth muscle | |||||
抄録 | ||||||
内容記述 | 神経解剖学者カハールが記載したといわれる腸管筋層固有の細胞は現在,カハールの介在細胞(ICC)と一般に呼ばれている.ICCは癌原遺伝子c-kitを発現し,その産物c-Kitレセプター依存性に分化,増殖する.そしてc-kitを指標として形態学的,生理学的研究が進展した.ICCには少なくとも2種類の機能および形態の異なるタイプが存在する.一つは消化管平滑筋に特徴的な律動的自動運動のペースメーカーであり,また他のグループは平滑筋と神経との間に介在して神経からの神経伝達の調節に関与している.ICCはその発生過程でも腸管神経と深く関わり,神経はc-Kitレセプターのリガンドを産生している. | |||||
言語 | ja | |||||
内容記述タイプ | Abstract | |||||
抄録 | ||||||
内容記述 | Interstitial cells of Cajal (ICC) were named after the famous neuroscientist Cajal SR. Recently it was found that ICC expressed proto-oncogene c-kit, needed for the growth and development of these cell. After that c-kit has become a good tool for both morphological and physiological studies of ICC. There are two types of ICC. One works as a pacemaker for the spontaneous contraction of smooth muscles in the gastrointestinal tract. These cells generate a pacemaker current and propagate to the smooth muscle through gap junctions to raise slow waves, and produce rhythmic contractions. The other ICC group is considered to be the neuro-modulators intercalated between enteric neurons and smooth muscles. These cells amplify nitrinergic and cholinergic neurotransmissions. Those ICC have several receptors of neurotransmitters such as neurokinin 1, somatostatin 2A, etc. In relation to the development of ICC, enteric neurons also show an close relationship to ICC inproducing stem cell factors, a ligand for c-Kit. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 日本メディカルセンター | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0911601X | |||||
書誌情報 |
ja : 臨牀消化器内科 巻 18, 号 10, p. 1371-1377, 発行日 2003 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/7893 | |||||
識別子タイプ | HDL |