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The role of bystin in embryo implantation and in ribosomal biogenesis
http://hdl.handle.net/2237/9027
http://hdl.handle.net/2237/90275a9026a3-b3a3-44dd-8282-e3f3e325a975
名前 / ファイル | ライセンス | アクション |
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CMLS-Bysl.pdf (996.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-11-21 | |||||
タイトル | ||||||
タイトル | The role of bystin in embryo implantation and in ribosomal biogenesis | |||||
言語 | en | |||||
著者 |
FUKUDA, Michiko N
× FUKUDA, Michiko N× MIYOSHI, Masaya× NADANO, Daita |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | The original publication is available at www.springerlink.com. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BYSL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enp1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ribosome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | embryo | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | trophoblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | placenta | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer | |||||
抄録 | ||||||
内容記述 | Human bystin was identified as a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. Although the trophinin gene is unique to mammals, the bystin gene (BYSL) is conserved across eukaryotes. Recent studies show that bystin plays a key role during the transition from silent trophectoderm to an active trophoblast upon trophinin-mediated cell adhesion. Bystin gene knockout and knockdown experiments demonstrate that bystin is essential for embryonic stem cell survival and trophectoderm development in the mouse. Furthermore, biochemical analysis of bystin in human cancer cells and mouse embryos indicates a function in ribosomal biogenesis, specifically in processing of 18S RNA in the 40S subunit. Strong evidence that BYSL is a target of c-MYC is consistent with bystin’s role in rapid protein synthesis, which is required for actively growing cells. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00018-007-7302-9 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1420-9071 | |||||
書誌情報 |
en : Cellular and Molecular Life Sciences 巻 65, 号 1, p. 92-99, 発行日 2007 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/9027 | |||||
識別子タイプ | HDL |