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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Nuclear localization of proteins with a charge periodicity of 28 residues

http://hdl.handle.net/2237/9292
http://hdl.handle.net/2237/9292
10545fdb-b598-487a-9cea-a0be9f2d9dc7
名前 / ファイル ライセンス アクション
7_35-J.pdf 7_35-J.pdf (11.5 kB)
7_35-E.pdf 7_35-E.pdf (282.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-01-15
タイトル
タイトル Nuclear localization of proteins with a charge periodicity of 28 residues
言語 en
その他のタイトル
その他のタイトル 電荷の28残基周期性を持ったタンパク質の核局在予測
言語 ja
著者 SAKIYAMA, Noriyuki

× SAKIYAMA, Noriyuki

WEKO 21368

en SAKIYAMA, Noriyuki

Search repository
崎山, 則征

× 崎山, 則征

WEKO 21369

ja 崎山, 則征

Search repository
KE, Runcong

× KE, Runcong

WEKO 21370

en KE, Runcong

Search repository
柯, 閏聡

× 柯, 閏聡

WEKO 21371

ja 柯, 閏聡

Search repository
SAWADA, Ryuusuke

× SAWADA, Ryuusuke

WEKO 21372

en SAWADA, Ryuusuke

Search repository
澤田, 隆介

× 澤田, 隆介

WEKO 21373

ja 澤田, 隆介

Search repository
SONOYAMA, Masashi

× SONOYAMA, Masashi

WEKO 21374

en SONOYAMA, Masashi

Search repository
園山, 正史

× 園山, 正史

WEKO 21375

ja 園山, 正史

Search repository
MITAKU, Shigeki

× MITAKU, Shigeki

WEKO 21376

en MITAKU, Shigeki

Search repository
美宅, 成樹

× 美宅, 成樹

WEKO 21377

ja 美宅, 成樹

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 proteome
キーワード
主題Scheme Other
主題 charge distribution
キーワード
主題Scheme Other
主題 nuclear localization protein
キーワード
主題Scheme Other
主題 prediction
キーワード
主題Scheme Other
主題 bioinformatics
キーワード
主題Scheme Other
主題 プロテオーム
キーワード
主題Scheme Other
主題 電荷分布
キーワード
主題Scheme Other
主題 核局在タンパク質
キーワード
主題Scheme Other
主題 予測
キーワード
主題Scheme Other
主題 バイオインフォマティクス
抄録
内容記述 Proteins with a charge periodicity of 28 residues (PCP28) were found recently in the human proteome, and many of the annotated PCP28 were located in the nucleus (Ke et al., Jpn. J.Appl.Phys. 2007). The physical properties of the amino acid sequences were analyzed to detect the difference in the physicochemistry between the nuclear and cytoplasmic PCP28 and develop a software system to classify the two types of PCP28. A significant difference in the global parameters from the entire sequence and the local parameters around a segment with the highest positive charge density was found between the nuclear and cytoplasmic PCP28. The global classification score included the densities of proline and cysteine, and the nagative charge density, while the local score included the symmetry of the charge distribution, the density of cysteine, and the positive charge density. A prediction system was developed using the global and local scores, which possessed a sensitivity and specificity of 92% and 88%, respectively. The mechanism of translocation of proteins to the nucleus is discussed using the parameters relevant to the predictive system.
言語 en
内容記述タイプ Abstract
抄録
内容記述 ヒトプロテオームにおいて電荷の28残基周期性を持ったタンパク質(PCP28)が発見され、PCP28の多くは核に局在していることが分かった(Ke et al., Jpn. J. Allp. Phys.2007)。核PCP28と細胞質PCP28のアミノ酸配列の物理化学的性質を解析し、物性の差からそれら二つのPCP28を分類するシステムを開発した。核PCP28と細胞質PCP28の間で、配列全体からのグローバルパラメータと高い電荷密度を持つセグメント周辺のローカルパラメータにおいて大きな違いが見られた。グローバルスコアではプロリン密度、システイン密度、負電荷密度に差があり、ローカルスコアでは電荷分布のシンメトリ、システイン密度、正電荷密度に差が見られた。これら二つのスコアを用いて予測システムを開発した結果、予測精度は感度が92%、特異性が97%であった。また、核へのタンパク質の輸送メカニズムを、予測システムに関連するパラメータから議論する。
言語 ja
内容記述タイプ Abstract
出版者
言語 en
出版者 Chem-Bio Informatics Society
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.cbi.or.jp/cbi/CBIj/vol7/7_35-E.pdf
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.cbi.or.jp/cbi/CBIj/vol7/7_35-J.pdf
書誌情報 en : Chem-Bio Informatics Journal

巻 7, 号 2, p. 35-48, 発行日 2007
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/9292
識別子タイプ HDL
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