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Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila
http://hdl.handle.net/2237/9393
http://hdl.handle.net/2237/9393adac2b4e-90ca-4b54-acfa-0f5aab872ca0
名前 / ファイル | ライセンス | アクション |
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DGD-dMi-2.pdf (2.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-02-04 | |||||
タイトル | ||||||
タイトル | Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila | |||||
言語 | en | |||||
著者 |
YAMASAKI, Yasutoyo
× YAMASAKI, Yasutoyo× NISHIDA, Yasuyoshi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NuRD complex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chromatin remodeling factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sensory organ development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proneural gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrochaete | |||||
抄録 | ||||||
内容記述 | Mi-2, the central component of the nucleosome remodeling and histone deacetylation (NuRD) complex, is known as an SNF2-type ATP-dependent nucleosome remodeling factor. No morphological mutant phenotype of Drosophila Mi-2 (dMi-2) had been reported previously, however, we found that rare escapers develop into adult flies showing an extra bristle phenotype. The dMi-2 enhanced the phenotype of ac^Hw49c, which is a dominant gain-of-function allele of achaete (ac) and produces extra bristles. Consistent with these observations, the ac-expressing proneural clusters were expanded, and extra sensory organ precursors (SOPs) were formed in the dMi-2 mutant wing discs. Immunostaining of polytene chromosome showed that dMi-2 binds to the ac locus, and dMi-2 and acetylated hisotones distribute on polytene chromosomes in a mutually exclusive manner. The chromatin immunoprecipitation assay of the wing imaginal disc also demonstrated a binding of dMi-2 on the ac locus. These results suggest that the Drosophila Mi-2/NuRD complex functions in neuronal differentiation through the repression of proneural gene expression by chromatin remodeling and histone deacetylation. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Blackwell | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1440-169X.2006.00880.x | |||||
書誌情報 |
en : Development, Growth & Differentiation 巻 48, 号 7, p. 411-418, 発行日 2006 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/9393 | |||||
識別子タイプ | HDL |