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  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila

http://hdl.handle.net/2237/9393
http://hdl.handle.net/2237/9393
adac2b4e-90ca-4b54-acfa-0f5aab872ca0
名前 / ファイル ライセンス アクション
DGD-dMi-2.pdf DGD-dMi-2.pdf (2.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-02-04
タイトル
タイトル Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila
言語 en
著者 YAMASAKI, Yasutoyo

× YAMASAKI, Yasutoyo

WEKO 21791

en YAMASAKI, Yasutoyo

Search repository
NISHIDA, Yasuyoshi

× NISHIDA, Yasuyoshi

WEKO 21792

en NISHIDA, Yasuyoshi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The definitive version is available at www.blackwell-synergy.com
キーワード
主題Scheme Other
主題 NuRD complex
キーワード
主題Scheme Other
主題 chromatin remodeling factor
キーワード
主題Scheme Other
主題 sensory organ development
キーワード
主題Scheme Other
主題 proneural gene
キーワード
主題Scheme Other
主題 macrochaete
抄録
内容記述 Mi-2, the central component of the nucleosome remodeling and histone deacetylation (NuRD) complex, is known as an SNF2-type ATP-dependent nucleosome remodeling factor. No morphological mutant phenotype of Drosophila Mi-2 (dMi-2) had been reported previously, however, we found that rare escapers develop into adult flies showing an extra bristle phenotype. The dMi-2 enhanced the phenotype of ac^Hw49c, which is a dominant gain-of-function allele of achaete (ac) and produces extra bristles. Consistent with these observations, the ac-expressing proneural clusters were expanded, and extra sensory organ precursors (SOPs) were formed in the dMi-2 mutant wing discs. Immunostaining of polytene chromosome showed that dMi-2 binds to the ac locus, and dMi-2 and acetylated hisotones distribute on polytene chromosomes in a mutually exclusive manner. The chromatin immunoprecipitation assay of the wing imaginal disc also demonstrated a binding of dMi-2 on the ac locus. These results suggest that the Drosophila Mi-2/NuRD complex functions in neuronal differentiation through the repression of proneural gene expression by chromatin remodeling and histone deacetylation.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Blackwell
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1440-169X.2006.00880.x
書誌情報 en : Development, Growth & Differentiation

巻 48, 号 7, p. 411-418, 発行日 2006
フォーマット
application/pdf
著者版フラグ
値 author
URI
識別子 http://hdl.handle.net/2237/9393
識別子タイプ HDL
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