{"_buckets": {"deposit": "1e4bef12-8d83-4083-848d-c35d131a94e6"}, "_deposit": {"id": "7682", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "7682"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00007682"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "418", "bibliographicPageStart": "411", "bibliographicVolumeNumber": "48", "bibliographic_titles": [{"bibliographic_title": "Development, Growth \u0026 Differentiation"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Mi-2, the central component of the nucleosome remodeling and histone deacetylation (NuRD) complex, is known as an SNF2-type ATP-dependent nucleosome remodeling factor. No morphological mutant phenotype of Drosophila Mi-2 (dMi-2) had been reported previously, however, we found that rare escapers develop into adult flies showing an extra bristle phenotype. The dMi-2 enhanced the phenotype of ac^Hw49c, which is a dominant gain-of-function allele of achaete (ac) and produces extra bristles. Consistent with these observations, the ac-expressing proneural clusters were expanded, and extra sensory organ precursors (SOPs) were formed in the dMi-2 mutant wing discs. Immunostaining of polytene chromosome showed that dMi-2 binds to the ac locus, and dMi-2 and acetylated hisotones distribute on polytene chromosomes in a mutually exclusive manner. The chromatin immunoprecipitation assay of the wing imaginal disc also demonstrated a binding of dMi-2 on the ac locus. These results suggest that the Drosophila Mi-2/NuRD complex functions in neuronal differentiation through the repression of proneural gene expression by chromatin remodeling and histone deacetylation.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/9393"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Blackwell"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1111/j.1440-169X.2006.00880.x", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "The definitive version is available at www.blackwell-synergy.com"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "YAMASAKI, Yasutoyo"}], "nameIdentifiers": [{"nameIdentifier": "21791", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NISHIDA, Yasuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "21792", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DGD-dMi-2.pdf", "filesize": [{"value": "2.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2900000.0, "url": {"label": "DGD-dMi-2.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/7682/files/DGD-dMi-2.pdf"}, "version_id": "e43be100-20aa-4880-95a8-6cc677df2b0d"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "NuRD complex", "subitem_subject_scheme": "Other"}, {"subitem_subject": "chromatin remodeling factor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "sensory organ development", "subitem_subject_scheme": "Other"}, {"subitem_subject": "proneural gene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrochaete", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila"}]}, "item_type_id": "10", "owner": "1", "path": ["336/695/696"], "permalink_uri": "http://hdl.handle.net/2237/9393", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2008-02-04"}, "publish_date": "2008-02-04", "publish_status": "0", "recid": "7682", "relation": {}, "relation_version_is_last": true, "title": ["Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila"], "weko_shared_id": 3}