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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 70(3-4)

EXPRESSION AND ROLES OF A XENOPUS HEAD-FORMING GENE HOMOLOGUE IN HUMAN CANCER CELL LINES

https://doi.org/10.18999/nagjms.70.3-4.73
https://doi.org/10.18999/nagjms.70.3-4.73
61ef9620-88f2-48d3-8317-7c426c1501a7
名前 / ファイル ライセンス アクション
p073-082_Zhu.pdf p073-082_Zhu.pdf (506.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2008-09-22
タイトル
タイトル EXPRESSION AND ROLES OF A XENOPUS HEAD-FORMING GENE HOMOLOGUE IN HUMAN CANCER CELL LINES
著者 ZHU, YINGSONG

× ZHU, YINGSONG

WEKO 24725

ZHU, YINGSONG

Search repository
TSUCHIDA, AKIKO

× TSUCHIDA, AKIKO

WEKO 24726

TSUCHIDA, AKIKO

Search repository
YAMAMOTO, AKIHITO

× YAMAMOTO, AKIHITO

WEKO 24727

YAMAMOTO, AKIHITO

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FURUKAWA, KEIKO

× FURUKAWA, KEIKO

WEKO 24728

FURUKAWA, KEIKO

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TAJIMA, ORIE

× TAJIMA, ORIE

WEKO 24729

TAJIMA, ORIE

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TOKUDA, NORIYO

× TOKUDA, NORIYO

WEKO 24730

TOKUDA, NORIYO

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AIZAWA, SHINICHI

× AIZAWA, SHINICHI

WEKO 24731

AIZAWA, SHINICHI

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URANO, TAKESHI

× URANO, TAKESHI

WEKO 24732

URANO, TAKESHI

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KADOMATSU, KENJI

× KADOMATSU, KENJI

WEKO 24733

KADOMATSU, KENJI

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FURUKAWA, KOICHI

× FURUKAWA, KOICHI

WEKO 24734

FURUKAWA, KOICHI

Search repository
キーワード
主題Scheme Other
主題 Head
キーワード
主題Scheme Other
主題 Wnt
キーワード
主題Scheme Other
主題 Frizzled
キーワード
主題Scheme Other
主題 Cancer
キーワード
主題Scheme Other
主題 Xenopus
抄録
内容記述 Molecular mechanisms for both morphogenesis and carcinogenesis have frequently overlapped, and similar signaling pathways are often involved in these processes. Yamamoto et al. identified a novel protein that induces head formation in Xenopus (Yamamoto et al. Cell, 120, 223-225, 2005). This new protein, named Shisa, plays unique roles in head formation by suppressing the maturation processes of receptors for Wnt and FGF at the endoplasmic reticulum. Here, we have identified a human homologue of the shisa gene (hu-shisa-2), and analyzed its expression in various human cancer cell lines by real-time reverse transcription polymerase chain reaction. High levels of mRNA expression were observed in some neuroectoderm-derived human cancer cell lines and small cell lung cancer cell lines. Intracellular localization of hu-Shisa-2 protein was also analyzed, indicating that it is present in the endoplasmic reticulum. Over-expression of hu-Shisa-2 resulted in increased cell growth and invasion, suggesting that hu-Shisa-2 is involved in the evolution and/or progression of human cancers.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.70.3-4.73
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 70, 号 3-4, p. 73-82, 発行日 2008-08
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/10543
識別子タイプ HDL
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