{"_buckets": {"deposit": "3eb7cfad-7ce4-4c78-98cd-9ddbc88a0a0f"}, "_deposit": {"id": "8791", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8791"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00008791"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3-4", "bibliographicPageEnd": "82", "bibliographicPageStart": "73", "bibliographicVolumeNumber": "70", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Molecular mechanisms for both morphogenesis and carcinogenesis have frequently overlapped, and similar signaling pathways are often involved in these processes. Yamamoto et al. identified a novel protein that induces head formation in Xenopus (Yamamoto et al. Cell, 120, 223-225, 2005). This new protein, named Shisa, plays unique roles in head formation by suppressing the maturation processes of receptors for Wnt and FGF at the endoplasmic reticulum. Here, we have identified a human homologue of the shisa gene (hu-shisa-2), and analyzed its expression in various human cancer cell lines by real-time reverse transcription polymerase chain reaction. High levels of mRNA expression were observed in some neuroectoderm-derived human cancer cell lines and small cell lung cancer cell lines. Intracellular localization of hu-Shisa-2 protein was also analyzed, indicating that it is present in the endoplasmic reticulum. Over-expression of hu-Shisa-2 resulted in increased cell growth and invasion, suggesting that hu-Shisa-2 is involved in the evolution and/or progression of human cancers.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/10543"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.70.3-4.73", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_9_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ZHU, YINGSONG"}], "nameIdentifiers": [{"nameIdentifier": "24725", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TSUCHIDA, AKIKO"}], "nameIdentifiers": [{"nameIdentifier": "24726", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YAMAMOTO, AKIHITO"}], "nameIdentifiers": [{"nameIdentifier": "24727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FURUKAWA, KEIKO"}], "nameIdentifiers": [{"nameIdentifier": "24728", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAJIMA, ORIE"}], "nameIdentifiers": [{"nameIdentifier": "24729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TOKUDA, NORIYO"}], "nameIdentifiers": [{"nameIdentifier": "24730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "AIZAWA, SHINICHI"}], "nameIdentifiers": [{"nameIdentifier": "24731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "URANO, TAKESHI"}], "nameIdentifiers": [{"nameIdentifier": "24732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KADOMATSU, KENJI"}], "nameIdentifiers": [{"nameIdentifier": "24733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FURUKAWA, KOICHI"}], "nameIdentifiers": [{"nameIdentifier": "24734", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "p073-082_Zhu.pdf", "filesize": [{"value": "506.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 506200.0, "url": {"label": "p073-082_Zhu.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/8791/files/p073-082_Zhu.pdf"}, "version_id": "8acc4faf-591e-4518-aff7-baa7699381cf"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Head", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Wnt", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Frizzled", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Xenopus", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "EXPRESSION AND ROLES OF A XENOPUS\u3000HEAD-FORMING GENE HOMOLOGUE\u3000IN HUMAN CANCER CELL LINES", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "EXPRESSION AND ROLES OF A XENOPUS\u3000HEAD-FORMING GENE HOMOLOGUE\u3000IN HUMAN CANCER CELL LINES"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/1048"], "permalink_uri": "https://doi.org/10.18999/nagjms.70.3-4.73", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2008-09-22"}, "publish_date": "2008-09-22", "publish_status": "0", "recid": "8791", "relation": {}, "relation_version_is_last": true, "title": ["EXPRESSION AND ROLES OF A XENOPUS\u3000HEAD-FORMING GENE HOMOLOGUE\u3000IN HUMAN CANCER CELL LINES"], "weko_shared_id": 3}