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EXPRESSION AND ROLES OF A XENOPUS HEAD-FORMING GENE HOMOLOGUE IN HUMAN CANCER CELL LINES
https://doi.org/10.18999/nagjms.70.3-4.73
https://doi.org/10.18999/nagjms.70.3-4.7361ef9620-88f2-48d3-8317-7c426c1501a7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
p073-082_Zhu.pdf (506.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-22 | |||||
| タイトル | ||||||
| タイトル | EXPRESSION AND ROLES OF A XENOPUS HEAD-FORMING GENE HOMOLOGUE IN HUMAN CANCER CELL LINES | |||||
| 言語 | en | |||||
| 著者 |
ZHU, YINGSONG
× ZHU, YINGSONG× TSUCHIDA, AKIKO× YAMAMOTO, AKIHITO× FURUKAWA, KEIKO× TAJIMA, ORIE× TOKUDA, NORIYO× AIZAWA, SHINICHI× URANO, TAKESHI× KADOMATSU, KENJI× FURUKAWA, KOICHI |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Head | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Wnt | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Frizzled | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Xenopus | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Molecular mechanisms for both morphogenesis and carcinogenesis have frequently overlapped, and similar signaling pathways are often involved in these processes. Yamamoto et al. identified a novel protein that induces head formation in Xenopus (Yamamoto et al. Cell, 120, 223-225, 2005). This new protein, named Shisa, plays unique roles in head formation by suppressing the maturation processes of receptors for Wnt and FGF at the endoplasmic reticulum. Here, we have identified a human homologue of the shisa gene (hu-shisa-2), and analyzed its expression in various human cancer cell lines by real-time reverse transcription polymerase chain reaction. High levels of mRNA expression were observed in some neuroectoderm-derived human cancer cell lines and small cell lung cancer cell lines. Intracellular localization of hu-Shisa-2 protein was also analyzed, indicating that it is present in the endoplasmic reticulum. Over-expression of hu-Shisa-2 resulted in increased cell growth and invasion, suggesting that hu-Shisa-2 is involved in the evolution and/or progression of human cancers. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.70.3-4.73 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 70, 号 3-4, p. 73-82, 発行日 2008-08 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/10543 | |||||
| 識別子タイプ | HDL | |||||
