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Repetitive Stretching Prevents Muscle Atrophy in Denervated Soleus Muscle via Akt/mTOR/p70S6K Pathways
http://hdl.handle.net/2237/11470
http://hdl.handle.net/2237/114701b21cd06-53c2-4f14-b9eb-3a06baaa8576
名前 / ファイル | ライセンス | アクション |
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k8251_thesis.pdf (1.5 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2009-04-16 | |||||
タイトル | ||||||
タイトル | Repetitive Stretching Prevents Muscle Atrophy in Denervated Soleus Muscle via Akt/mTOR/p70S6K Pathways | |||||
言語 | en | |||||
その他のタイトル | ||||||
その他のタイトル | 周期的伸張刺激はAkt/mTOR/p70S6K 経路を介して除神経によるヒラメ筋萎縮を抑制する | |||||
言語 | ja | |||||
著者 |
縣, 信秀
× 縣, 信秀× Agata, Nobuhide |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Akt | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | muscle atrophy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p70S6K | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rapamycin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | repetitive stretch | |||||
抄録 | ||||||
内容記述 | This study was conducted to examine whether stretch-related mechanical loading on skeletal muscle can suppress denervation-induced muscle atrophy, and if so, to depict the underlying molecular mechanism. Denervated rat soleus muscle was repetitively stretched (every 5 sec for 15 min/day) for 2 weeks. Histochemical analysis showed that the cross-sectional area of denervated soleus muscle fibers with repetitive stretching was significantly larger than that of control denervated muscle (p<0.05). We then examined the involvement of the Akt/mammalian target of the rapamycin (mTOR) cascade in the suppressive effects of repetitive stretching on muscle atrophy. Repetitive stretching significantly increased the Akt, p70S6K and 4E-BP1 phosphorylation in denervated soleus muscle compared to controls (p<0.05). Furthermore, repetitive stretching-induced suppression of muscle atrophy was fully inhibited by rapamycin, a potent inhibitor of mTOR. These results indicate that denervation-induced muscle atrophy is significantly suppressed by stretch-related mechanical loading of the muscle through upregulation of the Akt/mTOR signal pathway. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 名古屋大学博士学位論文 学位の種類:博士(医療技術学)(課程)学位授与年月日:平成21年3月25日 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
書誌情報 |
発行日 2009-03-25 |
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学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医療技術学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13901 | |||||
言語 | ja | |||||
学位授与機関名 | 名古屋大学 | |||||
言語 | en | |||||
学位授与機関名 | NAGOYA University | |||||
学位授与年度 | ||||||
学位授与年度 | 2008 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2009-03-25 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第8251号 | |||||
フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/11470 | |||||
識別子タイプ | HDL |