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Estrogen Enhances Vitamin D_3-mediated Expression of Osteocalcin mRNA by Increasing Vitamin D_3 Receptor Expression in Osteoblasts
https://doi.org/10.18999/envm.46.43
54c53181-15e9-43f4-93be-650f509f7643
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | Estrogen Enhances Vitamin D_3-mediated Expression of Osteocalcin mRNA by Increasing Vitamin D_3 Receptor Expression in Osteoblasts | |||||
著者 |
KAWANO, Setsuko
× KAWANO, Setsuko× KAMBE, Fukushi× KANDA, Kazumi× OHMORI, Sachiko× SEO, Hisao |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | estrogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 1α,25-dihydroxyvitamin D_3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteocalcin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 1α,25-dihydroxyvitamin D_3 receptor | |||||
抄録 | ||||||
内容記述 | Regulation of osteocalcin (OC) gene expression in osteoblasts by estrogen has been controversial. We thus investigated the effect of 17β-estradiol (Ea) on 1α,25-dihydroxyvitamin D_3 (VD_3)-mediated increase in the transcription of OC gene in rat osteoblastic ROS 17/2.8 cells. Treatment of the cells with E_2 or VD_3 alone did not increase OC mRNA. However, combined treatment with E_2 and VD_3 significantly increased the OC mRNA levels, suggesting that VD_3-dependent up-regulation of OC expression requires E_2 action. Since it was demonstrated that treatment with E_2 alone increased the expression of VD_3 receptor mRNA, it was suggested that E_2- mediated increase in the receptor number is contributing to VD_3-mediated increase in OC gene transcription. | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.43 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 43-44, 発行日 2002-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2779 | |||||
識別子タイプ | HDL |