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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Estrogen Enhances Vitamin D_3-mediated Expression of Osteocalcin mRNA by Increasing Vitamin D_3 Receptor Expression in Osteoblasts

https://doi.org/10.18999/envm.46.43
54c53181-15e9-43f4-93be-650f509f7643
名前 / ファイル ライセンス アクション
KJ00000034859.pdf KJ00000034859.pdf (210.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Estrogen Enhances Vitamin D_3-mediated Expression of Osteocalcin mRNA by Increasing Vitamin D_3 Receptor Expression in Osteoblasts
著者 KAWANO, Setsuko

× KAWANO, Setsuko

WEKO 3106

KAWANO, Setsuko

Search repository
KAMBE, Fukushi

× KAMBE, Fukushi

WEKO 3107

KAMBE, Fukushi

Search repository
KANDA, Kazumi

× KANDA, Kazumi

WEKO 3108

KANDA, Kazumi

Search repository
OHMORI, Sachiko

× OHMORI, Sachiko

WEKO 3109

OHMORI, Sachiko

Search repository
SEO, Hisao

× SEO, Hisao

WEKO 3110

SEO, Hisao

Search repository
キーワード
主題Scheme Other
主題 estrogen
キーワード
主題Scheme Other
主題 1α,25-dihydroxyvitamin D_3
キーワード
主題Scheme Other
主題 osteocalcin
キーワード
主題Scheme Other
主題 1α,25-dihydroxyvitamin D_3 receptor
抄録
内容記述 Regulation of osteocalcin (OC) gene expression in osteoblasts by estrogen has been controversial. We thus investigated the effect of 17β-estradiol (Ea) on 1α,25-dihydroxyvitamin D_3 (VD_3)-mediated increase in the transcription of OC gene in rat osteoblastic ROS 17/2.8 cells. Treatment of the cells with E_2 or VD_3 alone did not increase OC mRNA. However, combined treatment with E_2 and VD_3 significantly increased the OC mRNA levels, suggesting that VD_3-dependent up-regulation of OC expression requires E_2 action. Since it was demonstrated that treatment with E_2 alone increased the expression of VD_3 receptor mRNA, it was suggested that E_2- mediated increase in the receptor number is contributing to VD_3-mediated increase in OC gene transcription.
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
内容記述タイプ Other
出版者
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/envm.46.43
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 02870517
書誌情報 Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 43-44, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2779
識別子タイプ HDL
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