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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Homologous Recombination of Mouse ZAKI-4 Gene to Disrupt its Expression

https://doi.org/10.18999/envm.46.55
https://doi.org/10.18999/envm.46.55
310bd83a-9c4a-4b52-8e45-eb6dad6902e7
名前 / ファイル ライセンス アクション
KJ00000034863.pdf KJ00000034863.pdf (430.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Homologous Recombination of Mouse ZAKI-4 Gene to Disrupt its Expression
言語 en
著者 KANOU, Yasuhiko

× KANOU, Yasuhiko

WEKO 3129

en KANOU, Yasuhiko

Search repository
ABE, Naoki

× ABE, Naoki

WEKO 3130

en ABE, Naoki

Search repository
ISHIDA, Junji

× ISHIDA, Junji

WEKO 3131

en ISHIDA, Junji

Search repository
FUKAMIZU, Akiyoshi

× FUKAMIZU, Akiyoshi

WEKO 3132

en FUKAMIZU, Akiyoshi

Search repository
SEO, Hisao

× SEO, Hisao

WEKO 3133

en SEO, Hisao

Search repository
MURATA, Yoshiharu

× MURATA, Yoshiharu

WEKO 3134

en MURATA, Yoshiharu

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 ZAKI-4
キーワード
主題Scheme Other
主題 homologous recombination
キーワード
主題Scheme Other
主題 gene targeting
キーワード
主題Scheme Other
主題 calcineurin
抄録
内容記述 ZAKI-4 inhibits the activity of calcineurin, a Ca^<2+>-dependent protein phosphatase. From ZAKI-4 gene, two isoforms, a and P are generated by an alternative splicing. In adult mice ZAKI-4 α mRNA was mainly expressed in brain whereas ZAKI-4 β mRNA wasubiquitously. To elucidate the specific function of ZAKI-4 isoforms, we plan to establish ZAKI-4 β knock out mice by homologousrecombination. For this purpose, mouse embryonic stem cells were electroporated with a targeting vector in which ZAKI-4 β sequencewas disrupted by cDNA coding neomycin resistance. Six independent clones out of 466 antibiotics-resistant colonies underwenthomologous recombination at the ZAKI-4 β locus. These clones will be used to establish the knock out mice.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.55
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 55-57, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2783
識別子タイプ HDL
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