WEKO3
アイテム
{"_buckets": {"deposit": "64307365-0b12-4f69-9f05-12cb30d5103c"}, "_deposit": {"id": "1382", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1382"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00001382", "sets": []}, "author_link": ["3169", "3170", "3171"], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1/2", "bibliographicPageEnd": "85", "bibliographicPageStart": "84", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Mibefradil has been reported to preferentially block T-type Ca^\u003c2+\u003e channel currents in many different tissues including heart with variable potencies. We recorded T-type Ca^\u003c2+\u003e currents (I_\u003cCa-T\u003e) in early embryonic (9.5 day post coitum (dpc)) mouse ventricular myocytes using a whole-cell patch clamp method and studied the effects of mibefradil. ICa T were inhibited by mibefradil in a concentration- dependent manner with half inhibitory concentration (IC_\u003c50\u003e) at 3.4 ± 0.2 μM. This value is higher than those reported for native adult and neonatal atrial myocytes (0.1-1.5 μM). Factors affecting the mibefradil sensitivity of I_\u003cCa-T\u003e, in particular different subtypes of α1 subunits, are discussed.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "国立情報学研究所で電子化したコンテンツを使用している。", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/2792"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.46.84", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University", "subitem_publisher_language": "en"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "02870517", "subitem_source_identifier_type": "PISSN"}]}, "item_9_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NIWA, Noriko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3169", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YASUI, Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3170", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KODAMA, Itsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3171", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000034872.pdf", "filesize": [{"value": "217.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 217200.0, "url": {"label": "KJ00000034872.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/1382/files/KJ00000034872.pdf"}, "version_id": "738ab6a2-7205-44f9-9cb0-a44a4855b3ad"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "mibefradil", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T-type Ca^\u003c2+\u003e channels", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "1", "path": ["335"], "permalink_uri": "https://doi.org/10.18999/envm.46.84", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2006-01-05"}, "publish_date": "2006-01-05", "publish_status": "0", "recid": "1382", "relation": {}, "relation_version_is_last": true, "title": ["Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes"], "weko_shared_id": -1}
Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes
https://doi.org/10.18999/envm.46.84
https://doi.org/10.18999/envm.46.849f5ae25e-0ca3-4dbc-99f8-53af88800e63
名前 / ファイル | ライセンス | アクション |
---|---|---|
KJ00000034872.pdf (217.2 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | Inhibitory Action of Mibefradil on T-Type Calcium Channels in Early Embryonic Mouse Ventricular Myocytes | |||||
言語 | en | |||||
著者 |
NIWA, Noriko
× NIWA, Noriko× YASUI, Kenji× KODAMA, Itsuo |
|||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mibefradil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T-type Ca^<2+> channels | |||||
抄録 | ||||||
内容記述 | Mibefradil has been reported to preferentially block T-type Ca^<2+> channel currents in many different tissues including heart with variable potencies. We recorded T-type Ca^<2+> currents (I_<Ca-T>) in early embryonic (9.5 day post coitum (dpc)) mouse ventricular myocytes using a whole-cell patch clamp method and studied the effects of mibefradil. ICa T were inhibited by mibefradil in a concentration- dependent manner with half inhibitory concentration (IC_<50>) at 3.4 ± 0.2 μM. This value is higher than those reported for native adult and neonatal atrial myocytes (0.1-1.5 μM). Factors affecting the mibefradil sensitivity of I_<Ca-T>, in particular different subtypes of α1 subunits, are discussed. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.84 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 84-85, 発行日 2002-12 |
|||||
フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2792 | |||||
識別子タイプ | HDL |