{"_buckets": {"deposit": "3246bbc6-d17f-4d3b-9be4-0e932269634b"}, "_deposit": {"id": "2005303", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2005303"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02005303", "sets": ["1680485626845"]}, "author_link": [], "control_number": "2005303", "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Effect of C-peptide fragment on insulin action in STZ-induced diabetic rats", "subitem_alternative_title_language": "en"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-03-31", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "25", "bibliographicPageStart": "21", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "総合保健体育科学", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Nagoya Journal of Health, Physical Fitness \u0026 Sports", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Our previous studies suggest that C-peptide augments glucose utilization in strepotozotocin (STZ)-induced diabetic rats. The present study was undertaken to determine the influence of human C-peptide fragment (11-22) on in vivo glucose utilization in STZ-induced diabetic rats by using the sequential euglycemic clamp technique. Two different insulin infusion rates, 3.0 (low-dose) and 30.0 (high-dose) mU/kg/min were employed in the awake condition. Rat C-peptide I or human C-peptide fragment was infused at a rate of 0.05 nmol/kg/min, which increased plasma levels from 0.2 ± 0.1 to 12.3 ± 5.2 ng/ml, from 0.6 ± 0.1 to 22.5 ± 2.2 ng/ml, respectively. (fasting levels in controls were 4.7 ± 1.0 ng/ml). Plasma insulin level during the low-dose and high-dose insulin infusion were 30 and 400 μU/ml, respectively, and blood glucose was clamped at 140 mg/dl by periodic adjustment of i.v. glucose infusion rate. Glucose metabolic clearance rate (MCR) in diabetic rats given rat C-peptide I during the low-dose insulin clamp was 17.4 ± 2.9 ml/kg/min (n = 6) as compared to 8.3 ± 0.7 ml/kg/min (n = 6) in diabetic control rats (p\u003c0.05). Likewise, MCR in diabetic rats infused with human C-peptide fragment (11-22) (13.0 ± 3.2) tended to be 50% greater than in control diabetic rats, but not statistically significant. Rat C-peptide I and human C-peptide fragment (11-22) did not significantly influence MCR at the high-dose insulin clamps. It could be concluded that human C-peptide fragment (11-22) also has biological activity in glucose utilization.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/njhpfs.21.1.21", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "名古屋大学総合保健体育科学センター", "subitem_publisher_language": "ja"}, {"subitem_publisher": "The Research Center of Health, Physical Fitness and Sports, Nagoya University", "subitem_publisher_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "0289-5412", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "李, 玲", "creatorNameLang": "ja"}, {"creatorName": "LI, Ling", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "押田, 芳治", "creatorNameLang": "ja"}, {"creatorName": "OSHIDA, Yoshiharu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "羅, 偉権", "creatorNameLang": "ja"}, {"creatorName": "LUO, Weiquan", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "大竹, 康敬", "creatorNameLang": "ja"}, {"creatorName": "OHTAKE, Yasutake", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "JOHANSSON, Bo-Lennart", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "WAHREN, John", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "矢内原, 昇", "creatorNameLang": "ja"}, {"creatorName": "YANAIHARA, Noboru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "佐藤, 祐造", "creatorNameLang": "ja"}, {"creatorName": "SATO, Yuzo", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2023-04-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "njhpfs_21_1_21.pdf", "filesize": [{"value": "3.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 3100000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2005303/files/njhpfs_21_1_21.pdf"}, "version_id": "cbbc5a18-5127-4d8e-86c4-c34a42f199df"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "C-ペプチドフラグメントのインスリン作用に及ぼす影響", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "C-ペプチドフラグメントのインスリン作用に及ぼす影響", "subitem_title_language": "ja"}]}, "item_type_id": "40001", "owner": "1", "path": ["1680485626845"], "permalink_uri": "https://doi.org/10.18999/njhpfs.21.1.21", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2023-04-04"}, "publish_date": "2023-04-04", "publish_status": "0", "recid": "2005303", "relation": {}, "relation_version_is_last": true, "title": ["C-ペプチドフラグメントのインスリン作用に及ぼす影響"], "weko_shared_id": -1}
C-ペプチドフラグメントのインスリン作用に及ぼす影響
https://doi.org/10.18999/njhpfs.21.1.21
https://doi.org/10.18999/njhpfs.21.1.21