| Item type |
itemtype_ver1(1) |
| 公開日 |
2023-04-04 |
| タイトル |
|
|
タイトル |
C-ペプチドフラグメントのインスリン作用に及ぼす影響 |
|
言語 |
ja |
| その他のタイトル |
|
|
その他のタイトル |
Effect of C-peptide fragment on insulin action in STZ-induced diabetic rats |
|
言語 |
en |
| 著者 |
李, 玲
押田, 芳治
羅, 偉権
大竹, 康敬
JOHANSSON, Bo-Lennart
WAHREN, John
矢内原, 昇
佐藤, 祐造
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Our previous studies suggest that C-peptide augments glucose utilization in strepotozotocin (STZ)-induced diabetic rats. The present study was undertaken to determine the influence of human C-peptide fragment (11-22) on in vivo glucose utilization in STZ-induced diabetic rats by using the sequential euglycemic clamp technique. Two different insulin infusion rates, 3.0 (low-dose) and 30.0 (high-dose) mU/kg/min were employed in the awake condition. Rat C-peptide I or human C-peptide fragment was infused at a rate of 0.05 nmol/kg/min, which increased plasma levels from 0.2 ± 0.1 to 12.3 ± 5.2 ng/ml, from 0.6 ± 0.1 to 22.5 ± 2.2 ng/ml, respectively. (fasting levels in controls were 4.7 ± 1.0 ng/ml). Plasma insulin level during the low-dose and high-dose insulin infusion were 30 and 400 μU/ml, respectively, and blood glucose was clamped at 140 mg/dl by periodic adjustment of i.v. glucose infusion rate. Glucose metabolic clearance rate (MCR) in diabetic rats given rat C-peptide I during the low-dose insulin clamp was 17.4 ± 2.9 ml/kg/min (n = 6) as compared to 8.3 ± 0.7 ml/kg/min (n = 6) in diabetic control rats (p<0.05). Likewise, MCR in diabetic rats infused with human C-peptide fragment (11-22) (13.0 ± 3.2) tended to be 50% greater than in control diabetic rats, but not statistically significant. Rat C-peptide I and human C-peptide fragment (11-22) did not significantly influence MCR at the high-dose insulin clamps. It could be concluded that human C-peptide fragment (11-22) also has biological activity in glucose utilization. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
名古屋大学総合保健体育科学センター |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
The Research Center of Health, Physical Fitness and Sports, Nagoya University |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/njhpfs.21.1.21 |
|
ID登録タイプ |
JaLC |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0289-5412 |
| 書誌情報 |
ja : 総合保健体育科学
en : Nagoya Journal of Health, Physical Fitness & Sports
巻 21,
号 1,
p. 21-25,
発行日 1998-03-31
|
njhpfs_21_1_21.pdf (3.1 MB)
