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β3アドレナリン受容体およびβ2アドレナリン受容体遺伝子多型の運動時糖質代謝への寄与
https://doi.org/10.18999/njhpfs.39.1.11
https://doi.org/10.18999/njhpfs.39.1.1147196022-6d25-413a-8ba7-3718f1416e17
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
39-1-03.pdf (1.0 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-05-19 | |||||
| タイトル | ||||||
| タイトル | β3アドレナリン受容体およびβ2アドレナリン受容体遺伝子多型の運動時糖質代謝への寄与 | |||||
| 言語 | ja | |||||
| その他のタイトル | ||||||
| その他のタイトル | The polymorphisms in β3 and β2 adrenergic receptor gene were associated with glucose metabolism in acute and chronic exercise. | |||||
| 言語 | en | |||||
| 著者 |
近藤, 志保
× 近藤, 志保× 藤木, 理代× 山本, 明子× 石黒, 洋× KONDO, Shiho× FUJIKI, Kotoyo× YAMAMOTO, Akiko× ISHIGURO, Hiroshi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gene polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glucose metabolism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aerobic and resistance exercise | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [Aim] The purpose of this study is to investigate whether the Trp64Arg polymorphism in β3-Adrenergic receptor (β3AR) gene and the Arg16Gly in β2AR were associated with glucose metabolism in aerobic and resistance exercise. [Methods] Thirteen healthy Japanese women (21~22 years old, BMI: 20.2±1.6) were recruited. The subjects performed 4-week aerobic exercise program (rhythmic dance) at 60% of their maximal heart rate for 20 min/day. After 4-weeks interval they performed 4-week resistance exercise program (sit up, back extension, overhead press, squat, twist) for 10 min/day. Before and after intervention 75-g oral glucose tolerance test were performed. [Results] Eight subjects have wild type (Trp64) of β3AR which is the genotype with high lipolysis activity. Other five subjects have Trp64Arg in β3AR or homozygote of Arg16Gly in β2AR they are the genotypes with high glucose metabolism. In the subjects with high lipolysis type the level of Δ30-50 min glucose was significantly higher during the aerobic exercise compare to that in resting (43.4±17.5 vs. -0.5±20.3 mg/dl, p<0.05). After the intervention the level was reduced to 23.3±26.5 mg/dl. The level of Δ30-45 min glucose during the resistance exercise was 23.0±30.9 mg/dl. After the intervention that was kept at significantly higher level compare to that in resting (25.3±24.6 vs. -0.5±17.1 mg/dl, p<0.05). In the subjects with high glucose metabolism the level during the aerobic exercise was significantly higher compare to that in resting (40.0±9.2 vs. 12.0±11.1 mg/dl, p<0.05). After the intervention the level was kept at 45.0±32.4 mg/dl. The level of Δ30-45 min glucose was significantly higher during the resistance exercise compare to that in resting (46.8±22.8 vs. -1.4±14.8 mg/dl, p<0.05). After the intervention the level was reduced to 11.6±26.0 mg/dl. [Conclusion] Trp64Arg in β3AR and the Arg16Gly in β2AR were associated with glucose metabolism in acute and chronic aerobic and resistance exercise. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 名古屋大学総合保健体育科学センター | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/njhpfs.39.1.11 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0289-5412 | |||||
| 書誌情報 |
ja : 総合保健体育科学 巻 39, 号 1, p. 11-16, 発行日 2016-12-28 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/26374 | |||||
| 識別子タイプ | HDL | |||||
