{"_buckets": {"deposit": "e830a931-1a38-4720-b26e-f4570322591f"}, "_deposit": {"id": "24383", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "24383"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00024383"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "334", "bibliographicPageStart": "322", "bibliographicVolumeNumber": "25", "bibliographic_titles": [{"bibliographic_title": "Cell Metabolism"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Hypothalamic neuropeptide Y (NPY) elicits hunger responses to increase the chances of surviving starvation: an inhibition of metabolism and an increase in feeding. Here we elucidate a key central circuit mechanism through which hypothalamic NPY signals drive these hunger responses. GABAergic neurons in the intermediate and parvicellular reticular nuclei (IRt/PCRt) of the medulla oblongata, which are activated by NPY-triggered neural signaling from the hypothalamus, potentially through the nucleus tractus solitarius, mediate the NPY-induced inhibition of metabolic thermogenesis in brown adipose tissue (BAT) via their innervation of BAT sympathetic premotor neurons. Intriguingly, the GABAergic IRt/PCRt neurons innervating the BAT sympathetic premotor region also innervate the masticatory motor region, and stimulation of the IRt/PCRt elicits mastication and increases feeding as well as inhibits BAT thermogenesis. These results indicate that GABAergic IRt/PCRt neurons mediate hypothalamus-derived hunger signaling by coordinating both autonomic and feeding motor systems to reduce energy expenditure and to promote feeding.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "https://doi.org/10.1016/j.cmet.2016.12.002"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/26594"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1550-4131", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakamura, Yoshiko"}], "nameIdentifiers": [{"nameIdentifier": "72225", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagawa, Yuchio"}], "nameIdentifiers": [{"nameIdentifier": "72226", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morrison, Shaun F."}], "nameIdentifiers": [{"nameIdentifier": "72227", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "72228", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Final_manuscript.pdf", "filesize": [{"value": "9.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 9300000.0, "url": {"label": "Final_manuscript.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2018/02/01", "url": "https://nagoya.repo.nii.ac.jp/record/24383/files/Final_manuscript.pdf"}, "version_id": "89e93058-bdda-4fea-93a4-5b12fcf8a374"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/26594", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2017-06-07"}, "publish_date": "2017-06-07", "publish_status": "0", "recid": "24383", "relation": {}, "relation_version_is_last": true, "title": ["Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication"], "weko_shared_id": null}