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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication

http://hdl.handle.net/2237/26594
e4374001-3b88-4424-9f16-5b45d76639c2
名前 / ファイル ライセンス アクション
Final_manuscript.pdf Final_manuscript.pdf ファイル公開:2018/02/01 (9.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-06-07
タイトル
タイトル Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication
著者 Nakamura, Yoshiko

× Nakamura, Yoshiko

WEKO 72225

Nakamura, Yoshiko

Search repository
Yanagawa, Yuchio

× Yanagawa, Yuchio

WEKO 72226

Yanagawa, Yuchio

Search repository
Morrison, Shaun F.

× Morrison, Shaun F.

WEKO 72227

Morrison, Shaun F.

Search repository
Nakamura, Kazuhiro

× Nakamura, Kazuhiro

WEKO 72228

Nakamura, Kazuhiro

Search repository
権利
権利情報 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
抄録
内容記述 Hypothalamic neuropeptide Y (NPY) elicits hunger responses to increase the chances of surviving starvation: an inhibition of metabolism and an increase in feeding. Here we elucidate a key central circuit mechanism through which hypothalamic NPY signals drive these hunger responses. GABAergic neurons in the intermediate and parvicellular reticular nuclei (IRt/PCRt) of the medulla oblongata, which are activated by NPY-triggered neural signaling from the hypothalamus, potentially through the nucleus tractus solitarius, mediate the NPY-induced inhibition of metabolic thermogenesis in brown adipose tissue (BAT) via their innervation of BAT sympathetic premotor neurons. Intriguingly, the GABAergic IRt/PCRt neurons innervating the BAT sympathetic premotor region also innervate the masticatory motor region, and stimulation of the IRt/PCRt elicits mastication and increases feeding as well as inhibits BAT thermogenesis. These results indicate that GABAergic IRt/PCRt neurons mediate hypothalamus-derived hunger signaling by coordinating both autonomic and feeding motor systems to reduce energy expenditure and to promote feeding.
内容記述タイプ Abstract
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1550-4131
書誌情報 Cell Metabolism

巻 25, 号 2, p. 322-334, 発行日 2017-02
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1016/j.cmet.2016.12.002
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26594
識別子タイプ HDL
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