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De Novo Synthesis of Possible Candidates for the Inagami–Tamura Endogenous Digitalis-like Factor
http://hdl.handle.net/2237/27149
http://hdl.handle.net/2237/271494b5af26f-1091-4117-88a4-1a0f6e21b7ce
名前 / ファイル | ライセンス | アクション |
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revised_manuscript.pdf ファイル公開:2018/09/01 (609.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-12-07 | |||||
タイトル | ||||||
タイトル | De Novo Synthesis of Possible Candidates for the Inagami–Tamura Endogenous Digitalis-like Factor | |||||
言語 | en | |||||
著者 |
Nakazaki, Atsuo
× Nakazaki, Atsuo× Hashimoto, Keiko× Ikeda, Ai× Shibata, Takahiro× Nishikawa, Toshio |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in [The Journal of Organic Chemistry], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [http://pubs.acs.org/articlesonrequest/AOR-4SXiUUWhVWXaJhUPs93D].” | |||||
抄録 | ||||||
内容記述 | De novo synthesis of possible candidates for the Inagami–Tamura endogenous digitalis-like factor (EDLF) was achieved to validate a previously proposed structure. Our synthetic approach involves a highly regio- and diastereoselective Mizoroki–Heck reaction and a Friedel–Crafts-type cyclodehydration to construct steroidal tetracycle 14 as a versatile common intermediate leading to seven 2,14β-dihydroxyestradiol analogues 1a–c, 2a–c, and 3 as possible candidates. By comparing the potency of inhibitory activity against Na+/K+-ATPase between the synthesized candidates and the EDLF, it was found that the proposed structure is not likely to be a true structure of the Inagami–Tamura EDLF. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | ACS Publications | |||||
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言語 | eng | |||||
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資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1021/acs.joc.7b01640 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0022-3263 | |||||
書誌情報 |
en : The Journal of Organic Chemistry 巻 82, 号 17, p. 9097-9111, 発行日 2017-09 |
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著者版フラグ | ||||||
値 | author | |||||
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識別子 | http://doi.org/10.1021/acs.joc.7b01640 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/27149 | |||||
識別子タイプ | HDL |