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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Manganese-mediated decrease in levels of c-RET and tyrosine hydroxylase expression in vitro

http://hdl.handle.net/2237/27152
32eb0885-593d-46cc-84fd-2719eb471117
名前 / ファイル ライセンス アクション
Kumasaka_et_al.pdf Kumasaka_et_al.pdf ファイル公開日:2018/11/01 (2.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-12-07
タイトル
タイトル Manganese-mediated decrease in levels of c-RET and tyrosine hydroxylase expression in vitro
著者 Kumasaka, Mayuko Y.

× Kumasaka, Mayuko Y.

WEKO 74266

Kumasaka, Mayuko Y.

Search repository
Yajima, Ichiro

× Yajima, Ichiro

WEKO 74267

Yajima, Ichiro

Search repository
Ohgami, Nobutaka

× Ohgami, Nobutaka

WEKO 74268

Ohgami, Nobutaka

Search repository
Ninomiya, Hiromasa

× Ninomiya, Hiromasa

WEKO 74269

Ninomiya, Hiromasa

Search repository
Iida, Machiko

× Iida, Machiko

WEKO 74270

Iida, Machiko

Search repository
Li, Xiang

× Li, Xiang

WEKO 74271

Li, Xiang

Search repository
Oshino, Reina

× Oshino, Reina

WEKO 74272

Oshino, Reina

Search repository
Tanihata, Hiroko

× Tanihata, Hiroko

WEKO 74273

Tanihata, Hiroko

Search repository
Yoshinaga, Masafumi

× Yoshinaga, Masafumi

WEKO 74274

Yoshinaga, Masafumi

Search repository
Kato, Masashi

× Kato, Masashi

WEKO 74275

Kato, Masashi

Search repository
権利
権利情報 The final publication is available at Springer via http://doi.org/10.1007/s12640-017-9783-0
キーワード
主題Scheme Other
主題 Manganese
キーワード
主題Scheme Other
主題 Metals
キーワード
主題Scheme Other
主題 Protein expression
キーワード
主題Scheme Other
主題 RET
キーワード
主題Scheme Other
主題 Tyrosine kinase
抄録
内容記述 Previous studies showed that overexposure to manganese causes parkinsonism, a disorder of dopaminergic neurons. Previous studies also showed that activity of c-RET kinase controls dopamine production through regulation of tyrosine hydroxylase (TH) expression, suggesting the involvement of c-RET in the development of parkinsonism. To our knowledge, however, there is no report showing a correlation between manganese-mediated parkinsonism and c-RET. In this study, we examined the effect of manganese on the expression and/or activation levels of c-RET and TH in human TH-expressing cells (TGW cells). We first found that treatment with 30 and 100 μM manganese resulted in reduction of c-RET transcript level and degradation of c-RET protein through promotion of ubiquitination. We then examined the biological significance of manganese-mediated decrease of c-RET protein expression. Decreased TH expression with decreased c-RET kinase activity was observed in c-RET protein-depleted TGW cells by treatment with manganese (30 μM) as well as by c-RET siRNA transfection. Since TH protein has been shown to be involved in the dopamine-producing pathway in previous studies, our results indicate the possibility that manganese-mediated reduction of TH expression and phosphorylation via decreased expression of c-RET protein in neural cells is involved in parkinsonism induced by manganese.
内容記述タイプ Abstract
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1029-8428
書誌情報 Neurotoxicity Research

巻 32, 号 4, p. 661-670, 発行日 2017-11
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1007/s12640-017-9783-0
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27152
識別子タイプ HDL
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