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Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair
http://hdl.handle.net/2237/00028291
http://hdl.handle.net/2237/00028291a0ad0b42-d10e-4625-b31f-1e995ef12141
名前 / ファイル | ライセンス | アクション |
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Uchida_et_al (3.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-11 | |||||
タイトル | ||||||
タイトル | Chemical hijacking of auxin signaling with an engineered auxin–TIR1 pair | |||||
言語 | en | |||||
著者 |
Uchida, Naoyuki
× Uchida, Naoyuki× Takahashi, Koji× Iwasaki, Rie× Yamada, Ryotaro× Yoshimura, Masahiko× Endo, Takaho A× Kimura, Seisuke× Zhang, Hua× Nomoto, Mika× Tada, Yasuomi× Kinoshita, Toshinori× Itami, Kenichiro× Hagihara, Shinya× Torii, Keiko U |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The phytohormone auxin indole-3-acetic acid (IAA) regulates nearly all aspects of plant growth and development. Despite substantial progress in our understanding of auxin biology, delineating specific auxin response remains a major challenge. Auxin regulates transcriptional response via its receptors, TIR1 and AFB F-box proteins. Here we report an engineered, orthogonal auxin–TIR1 receptor pair, developed through a bump-and-hole strategy, that triggers auxin signaling without interfering with endogenous auxin or TIR1/AFBs. A synthetic, convex IAA (cvxIAA) hijacked the downstream auxin signaling in vivo both at the transcriptomic level and in specific developmental contexts, only in the presence of a complementary, concave TIR1 (ccvTIR1) receptor. Harnessing the cvxIAA–ccvTIR1 system, we provide conclusive evidence for the role of the TIR1-mediated pathway in auxin-induced seedling acid growth. The cvxIAA–ccvTIR1 system serves as a powerful tool for solving outstanding questions in auxin biology and for precise manipulation of auxin-mediated processes as a controllable switch. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ファイル公開:2018-07-22 | |||||
言語 | ja | |||||
出版者 | ||||||
出版者 | nature | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/nchembio.2555 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1552-4450 | |||||
書誌情報 |
en : Nature Chemical Biology 巻 14, 号 3, p. 299-305, 発行日 2018-01-22 |
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著者版フラグ | ||||||
値 | author |