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  1. H120 物質科学国際研究センター
  2. H120a 雑誌掲載論文
  3. 学術雑誌

Catalytic Transfer Hydration of Cyanohydrins to α-Hydroxyamides

http://hdl.handle.net/2237/00030146
http://hdl.handle.net/2237/00030146
5de8e361-9548-40ba-9998-8ea65f503f06
名前 / ファイル ライセンス アクション
SubmittedText.pdf SubmittedText (1.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-05-09
タイトル
タイトル Catalytic Transfer Hydration of Cyanohydrins to α-Hydroxyamides
言語 en
著者 Kanda, Tomoya

× Kanda, Tomoya

WEKO 90988

en Kanda, Tomoya

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Naraoka, Asuka

× Naraoka, Asuka

WEKO 90989

en Naraoka, Asuka

Search repository
Naka, Hiroshi

× Naka, Hiroshi

WEKO 90990

en Naka, Hiroshi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This document is the Accepted Manuscript version of a Published Work that appeared in final form in [Journal of the American Chemical Society], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-G2mCKTXg7y5BCEnWAmU9].”
抄録
内容記述 We report the palladium(II)-catalyzed transfer hydration of cyanohydrins to α-hydroxyamides by using carboxamides as water donors. This method enables selective hydration of various aldehyde- and ketone-derived cyanohydrins to afford α-mono- and α,α-disubstituted-α-hydroxyamides, respectively, under mild conditions (50 °C, 10 min). The direct conversion of fenofibrate, a drug bearing a benzophenone moiety, into a functionalized α,α-diaryl-α-hydroxyamide was achieved by means of a hydrocyanation–transfer hydration sequence. Preliminary kinetic studies and the synthesis of a site-specifically 18O-labeled α-hydroxyamide demonstrated the carbonyl oxygen transfer from the carboxamide reagent into the α-hydroxyamide product.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020-01-16
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 ACS Publications
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1021/jacs.8b12877
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0002-7863
書誌情報 en : Journal of the American Chemical Society

巻 141, 号 2, p. 825-830, 発行日 2019-01-16
著者版フラグ
値 author
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