{"_buckets": {"deposit": "c84f5d9e-2687-4c66-ad5e-aee8fa12fcf1"}, "_deposit": {"id": "27947", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "27947"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00027947"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-01-16", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "830", "bibliographicPageStart": "825", "bibliographicVolumeNumber": "141", "bibliographic_titles": [{"bibliographic_title": "Journal of the American Chemical Society"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We report the palladium(II)-catalyzed transfer hydration of cyanohydrins to \u03b1-hydroxyamides by using carboxamides as water donors. This method enables selective hydration of various aldehyde- and ketone-derived cyanohydrins to afford \u03b1-mono- and \u03b1,\u03b1-disubstituted-\u03b1-hydroxyamides, respectively, under mild conditions (50 \u00b0C, 10 min). The direct conversion of fenofibrate, a drug bearing a benzophenone moiety, into a functionalized \u03b1,\u03b1-diaryl-\u03b1-hydroxyamide was achieved by means of a hydrocyanation\u2013transfer hydration sequence. Preliminary kinetic studies and the synthesis of a site-specifically 18O-labeled \u03b1-hydroxyamide demonstrated the carbonyl oxygen transfer from the carboxamide reagent into the \u03b1-hydroxyamide product.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2020-01-16", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "ACS Publications"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1021/jacs.8b12877", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u201cThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [Journal of the American Chemical Society], copyright \u00a9 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-G2mCKTXg7y5BCEnWAmU9].\u201d"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0002-7863", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kanda, Tomoya"}], "nameIdentifiers": [{"nameIdentifier": "90988", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naraoka, Asuka"}], "nameIdentifiers": [{"nameIdentifier": "90989", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naka, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "90990", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-01-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "SubmittedText.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "SubmittedText", "url": "https://nagoya.repo.nii.ac.jp/record/27947/files/SubmittedText.pdf"}, "version_id": "fd824978-e6e3-4569-b451-d57555041749"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Catalytic Transfer Hydration of Cyanohydrins to \u03b1-Hydroxyamides", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Catalytic Transfer Hydration of Cyanohydrins to \u03b1-Hydroxyamides"}]}, "item_type_id": "10", "owner": "1", "path": ["1917/1918/1919"], "permalink_uri": "http://hdl.handle.net/2237/00030146", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-05-09"}, "publish_date": "2019-05-09", "publish_status": "0", "recid": "27947", "relation": {}, "relation_version_is_last": true, "title": ["Catalytic Transfer Hydration of Cyanohydrins to \u03b1-Hydroxyamides"], "weko_shared_id": null}