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Total Synthesis of Tetrodotoxin
http://hdl.handle.net/2237/00032326
http://hdl.handle.net/2237/00032326d0de72ad-24b8-4c99-929e-1275fbe992e0
名前 / ファイル | ライセンス | アクション |
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20200122_ttx_ACIE_revision_tc (759.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-10 | |||||
タイトル | ||||||
タイトル | Total Synthesis of Tetrodotoxin | |||||
言語 | en | |||||
著者 |
Murakami, Keigo
× Murakami, Keigo× Toma, Tatsuya× Fukuyama, Tohru× Yokoshima, Satoshi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: [K. Murakami, T. Toma, T. Fukuyama, S. Yokoshima, Angew. Chem. Int. Ed. 2020 , 59 , 6253.], which has been published in final form at [https://doi.org/10.1002/anie.201916611]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
抄録 | ||||||
内容記述 | A total synthesis of tetrodotoxin was accomplished. A Diels–Alder reaction between a known enone and a siloxy diene gave a tricyclic product, the steric bias of which was used to construct the remaining stereogenic centers. A nitrogen atom was introduced either by a four‐step sequence involving a Curtius rearrangement, or a three‐step sequence featuring a newly developed transformation of a terminal alkyne into a nitrile. Introduction of the guanidine moiety followed by the formation of the heterocyclic system by cascade reactions led to tetrodotoxin. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2021-04-06 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Wiley | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/anie.201916611 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1433-7851 | |||||
書誌情報 |
en : Angewandte Chemie International Edition 巻 59, 号 15, p. 6253-6257, 発行日 2020-04-06 |
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著者版フラグ | ||||||
値 | author |