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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 63(1-2)

Identification of plasma antibody epitopes and gene abnormalities in Japanese hemophilia a patients with factor VIII inhibitor

https://doi.org/10.18999/nagjms.63.1-2.25
https://doi.org/10.18999/nagjms.63.1-2.25
91720df1-c12a-4753-880f-3f6a7df2344c
名前 / ファイル ライセンス アクション
nj6314.pdf nj6314.pdf (267.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-03
タイトル
タイトル Identification of plasma antibody epitopes and gene abnormalities in Japanese hemophilia a patients with factor VIII inhibitor
著者 Sugihara, Takuro

× Sugihara, Takuro

WEKO 9984

Sugihara, Takuro

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Takahashi, Isao

× Takahashi, Isao

WEKO 9985

Takahashi, Isao

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Kojima, Tetsuhito

× Kojima, Tetsuhito

WEKO 9986

Kojima, Tetsuhito

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Okamoto, Yoshihiro

× Okamoto, Yoshihiro

WEKO 9987

Okamoto, Yoshihiro

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Yamamoto, Koji

× Yamamoto, Koji

WEKO 9988

Yamamoto, Koji

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Kamiya, Tadashi

× Kamiya, Tadashi

WEKO 9989

Kamiya, Tadashi

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Matsushita, Tadashi

× Matsushita, Tadashi

WEKO 9990

Matsushita, Tadashi

Search repository
Saito, Hidehiko

× Saito, Hidehiko

WEKO 9991

Saito, Hidehiko

Search repository
キーワード
主題Scheme Other
主題 Factor VIII
キーワード
主題Scheme Other
主題 Hemophilia A
キーワード
主題Scheme Other
主題 Factor VIII inhibitor
キーワード
主題Scheme Other
主題 Southern blotting
キーワード
主題Scheme Other
主題 Gene inversion
抄録
内容記述 Eleven Japanese hemophilia A patients with anti-factor VIII (FVIII)a) inhibitors were studied to localize both their inhibitory antibody epitopes and their genotypes. The inhibitor epitopes were studied in nine severe hemophilia A patients by means of a scanning method using the oligopeptide panel covering the FVIII polypeptides without the B domain. The 107 15 mer-peptides were synthesized on solid-phase pins and analyzed for their reactivity with diluted patient plasma. As indicated previously, a series of peptides corresponding to the A2 and C2 domains were recognized by plasma antibodies from 2 patients and 4 patients, respectively. In contrast, all the antibodies bound to several epitopes in the A3 domain, while an epitope 1809-1821 covering the putative factor IX binding site was found in 3 patients. Southern blotting analysis showed that 8 out of 11 patients had either gene deletions or inversions of the FVIII gene, indicating a higher proportion of gross gene alterations in inhibitor-positive hemophilia A patients. However, the correlation of gene abnormality type with epitope location was not fully established.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.63.1-2.25
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 63, 号 1-2, p. 25-39, 発行日 2000-05
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5351
識別子タイプ HDL
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