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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 67(3-4)

Requirement of Multiple Signaling Pathways for the Augmented Production of Hyaluronan by V-SRC

https://doi.org/10.18999/nagjms.67.3-4.101
https://doi.org/10.18999/nagjms.67.3-4.101
8b4f7c7a-8b9a-4e4d-be6c-596527a10bdb
名前 / ファイル ライセンス アクション
p101NAITO.pdf p101NAITO.pdf (322.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-02-10
タイトル
タイトル Requirement of Multiple Signaling Pathways for the Augmented Production of Hyaluronan by V-SRC
著者 Naito, Yuko

× Naito, Yuko

WEKO 10202

Naito, Yuko

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Suzuki, Noriko

× Suzuki, Noriko

WEKO 10203

Suzuki, Noriko

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Huang, Pengyu

× Huang, Pengyu

WEKO 10204

Huang, Pengyu

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Hasegawa, Hitoki

× Hasegawa, Hitoki

WEKO 10205

Hasegawa, Hitoki

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Sohara, Yasuyoshi

× Sohara, Yasuyoshi

WEKO 10206

Sohara, Yasuyoshi

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Iwamoto, Takashi

× Iwamoto, Takashi

WEKO 10207

Iwamoto, Takashi

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Hamaguchi, Michinari

× Hamaguchi, Michinari

WEKO 10208

Hamaguchi, Michinari

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キーワード
主題Scheme Other
主題 Hyaluronan
キーワード
主題Scheme Other
主題 v-Src
キーワード
主題Scheme Other
主題 Signaling
キーワード
主題Scheme Other
主題 Ras
キーワード
主題Scheme Other
主題 MEK1
抄録
内容記述 Malignant transformation of cells is frequently associated with an augmented production of hyaluronan and the subsequent formation of a hyaluronan-matrix. In v-Src-transformed cells, hyaluronan directly activate cell motility in a tumor-specifi c manner. Despite its importance, the mechanism by which v-Src activates hyaluronan production remains unclear. Here we report that multiple signaling pathways are required for the augmented production of hyaluronan. Either the expression of a dominant negative Ras or the treatment of cells with manumycin A, a Ras farnesyltransferase inhibitor, was able to suppress hyaluronan production. In contrast, expression of MEK1EE, a constitutive form of MEK1, activated both hyaluronan synthase expression and hyaluronan production. AG-490, a Jak-2 inhibitor, or LY294002, a PI3K inhibitor, similarly suppressed the augmented production of hyarulonan. Taken together, our results suggest the involvement of multiple signaling pathways, including Ras-dependent and independent ones, in augmented hyaluronan production by v-Src.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.67.3-4.101
ID登録タイプ JaLC
書誌情報 Nagoya Journal of Medical Science

巻 67, 号 3-4, p. 101-108, 発行日 2005-06
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/5410
識別子タイプ HDL
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