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Requirement of Multiple Signaling Pathways for the Augmented Production of Hyaluronan by V-SRC
https://doi.org/10.18999/nagjms.67.3-4.101
https://doi.org/10.18999/nagjms.67.3-4.1018b4f7c7a-8b9a-4e4d-be6c-596527a10bdb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
p101NAITO.pdf (322.3 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-02-10 | |||||
| タイトル | ||||||
| タイトル | Requirement of Multiple Signaling Pathways for the Augmented Production of Hyaluronan by V-SRC | |||||
| 言語 | en | |||||
| 著者 |
Naito, Yuko
× Naito, Yuko× Suzuki, Noriko× Huang, Pengyu× Hasegawa, Hitoki× Sohara, Yasuyoshi× Iwamoto, Takashi× Hamaguchi, Michinari |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hyaluronan | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | v-Src | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Signaling | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ras | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MEK1 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Malignant transformation of cells is frequently associated with an augmented production of hyaluronan and the subsequent formation of a hyaluronan-matrix. In v-Src-transformed cells, hyaluronan directly activate cell motility in a tumor-specifi c manner. Despite its importance, the mechanism by which v-Src activates hyaluronan production remains unclear. Here we report that multiple signaling pathways are required for the augmented production of hyaluronan. Either the expression of a dominant negative Ras or the treatment of cells with manumycin A, a Ras farnesyltransferase inhibitor, was able to suppress hyaluronan production. In contrast, expression of MEK1EE, a constitutive form of MEK1, activated both hyaluronan synthase expression and hyaluronan production. AG-490, a Jak-2 inhibitor, or LY294002, a PI3K inhibitor, similarly suppressed the augmented production of hyarulonan. Taken together, our results suggest the involvement of multiple signaling pathways, including Ras-dependent and independent ones, in augmented hyaluronan production by v-Src. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.67.3-4.101 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 67, 号 3-4, p. 101-108, 発行日 2005-06 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/5410 | |||||
| 識別子タイプ | HDL | |||||
