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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 47

Voltage-Dependent Effects of Amiodarone on D540K HERG Channels

https://doi.org/10.18999/envm.47.51
https://doi.org/10.18999/envm.47.51
d4cc7af7-3221-4d22-9d49-66f3a36eed7d
名前 / ファイル ライセンス アクション
51-52.pdf 51-52.pdf (202.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-04-06
タイトル
タイトル Voltage-Dependent Effects of Amiodarone on D540K HERG Channels
言語 en
著者 Niwa, Ryoko

× Niwa, Ryoko

WEKO 15904

en Niwa, Ryoko

Search repository
Shimizu, Atsuya

× Shimizu, Atsuya

WEKO 15905

en Shimizu, Atsuya

Search repository
Lu, Zhibo

× Lu, Zhibo

WEKO 15906

en Lu, Zhibo

Search repository
Honjo, Haruo

× Honjo, Haruo

WEKO 15907

en Honjo, Haruo

Search repository
Kamiya, Kaichiro

× Kamiya, Kaichiro

WEKO 15908

en Kamiya, Kaichiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 amiodarone
キーワード
主題Scheme Other
主題 potassium channels
キーワード
主題Scheme Other
主題 arrhythmia
抄録
内容記述 To address the question of whether depolarization or channel opening facilitates drug binding, we studied the voltage-dependent block by amiodarone, a positively charged drug, on D540K HERG channels expressed in Xenopus oocytes. At 0 mV, amiodarone caused a concentration-dependent inhibition of D540K HERG current with IC_<50> of 15±5 μM(n=4). At-150 mV, inhibition by amiodarone was almost abolished (IC_<50> :>10 mM, n=4). These results suggest that binding of positively charged drug is augmented at depolarization and diminished at hyperpolarization if the channel remains open.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.47.51
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0287-0517
書誌情報 en : Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 47, p. 51-52, 発行日 2003-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/7587
識別子タイプ HDL
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