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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 71(1-2)

INVOLVEMENT OF DNA FRAGMENTATION OF ENTEROCYTES IN MUCOSAL INJURY TO A MOUSE JEJUNUM INCUBATED IN USSING CHAMBERS

https://doi.org/10.18999/nagjms.71.1-2.11
https://doi.org/10.18999/nagjms.71.1-2.11
67f1c546-8490-4ae5-9b3c-7f06e30bb577
名前 / ファイル ライセンス アクション
p011-018_Tachibana.pdf p011-018_Tachibana.pdf (611.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2009-03-16
タイトル
タイトル INVOLVEMENT OF DNA FRAGMENTATION OF ENTEROCYTES IN MUCOSAL INJURY TO A MOUSE JEJUNUM INCUBATED IN USSING CHAMBERS
著者 INAGAKI-TACHIBANA, EIKO

× INAGAKI-TACHIBANA, EIKO

WEKO 27534

INAGAKI-TACHIBANA, EIKO

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TSUKAHARA, TAKAMITSU

× TSUKAHARA, TAKAMITSU

WEKO 27535

TSUKAHARA, TAKAMITSU

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KAJI, KAZUHIKO

× KAJI, KAZUHIKO

WEKO 27536

KAJI, KAZUHIKO

Search repository
EGUCHI, RYOJI

× EGUCHI, RYOJI

WEKO 27537

EGUCHI, RYOJI

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KANAZAWA, HIROAKI

× KANAZAWA, HIROAKI

WEKO 27538

KANAZAWA, HIROAKI

Search repository
HAYASHI, HISAYOSHI

× HAYASHI, HISAYOSHI

WEKO 27539

HAYASHI, HISAYOSHI

Search repository
SUZUKI, YUICHI

× SUZUKI, YUICHI

WEKO 27540

SUZUKI, YUICHI

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キーワード
主題Scheme Other
主題 Apoptosis
キーワード
主題Scheme Other
主題 DNA ladder
キーワード
主題Scheme Other
主題 TUNEL staining
キーワード
主題Scheme Other
主題 Villus
キーワード
主題Scheme Other
主題 Intestinal barrier
抄録
内容記述 A mouse jejunum, when incubated in vitro in Ussing chambers, was found to exhibit morphological deterioration of the villi with denudation of the epithelia (J Nutr Sci Vitaminol, 51: 406, 2005). Our study examined the involvement of apoptosis in an intestinal injury model by a DNA ladder assay and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay. Electrophoresis of mucosal DNA revealed ladders, indicating the occurrence of DNA fragmentation. Cells with TUNEL-positive nuclei were detected among the villus epithelial cells (enterocytes), whereas they are rarely seen among crypt epithelial cells. These features were evident within 1 h after the start of incubation. Apoptotic death of the enterocytes was thus involved in the destruction of villi when incubated in Ussing chambers.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.71.1-2.11
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 71, 号 1-2, p. 11-18, 発行日 2009-02
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/11332
識別子タイプ HDL
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