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High levels of boron promote anchorage-independent growth of nontumorigenic cells
http://hdl.handle.net/2237/00033613
http://hdl.handle.net/2237/00033613686c99fa-50d6-4e87-807d-ed006dd14ad3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ENVIRONMENTAL_POLLUTION_2020_266_115094 (763.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-02-15 | |||||
| タイトル | ||||||
| タイトル | High levels of boron promote anchorage-independent growth of nontumorigenic cells | |||||
| 言語 | en | |||||
| 著者 |
Xu, Huadong
× Xu, Huadong× Hashimoto, Kazunori× Maeda, Masao× Azimi, Mohammad Daud× Fayaz, Said Hafizullah× Chen, Wei× Hamajima, Nobuyuki× Kato, Masashi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Boron | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Well drinking water | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tumorigenic risk | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tumorigenic pathway | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2022-11-01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.envpol.2020.115094 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0269-7491 | |||||
| 書誌情報 |
en : Environmental Pollution 巻 266, p. 115094, 発行日 2020-11 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
