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High levels of boron promote anchorage-independent growth of nontumorigenic cells
http://hdl.handle.net/2237/00033613
http://hdl.handle.net/2237/00033613686c99fa-50d6-4e87-807d-ed006dd14ad3
名前 / ファイル | ライセンス | アクション |
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ENVIRONMENTAL_POLLUTION_2020_266_115094 (763.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-15 | |||||
タイトル | ||||||
タイトル | High levels of boron promote anchorage-independent growth of nontumorigenic cells | |||||
言語 | en | |||||
著者 |
Xu, Huadong
× Xu, Huadong× Hashimoto, Kazunori× Maeda, Masao× Azimi, Mohammad Daud× Fayaz, Said Hafizullah× Chen, Wei× Hamajima, Nobuyuki× Kato, Masashi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Boron | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Well drinking water | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumorigenic risk | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumorigenic pathway | |||||
抄録 | ||||||
内容記述 | WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2022-11-01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.envpol.2020.115094 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0269-7491 | |||||
書誌情報 |
en : Environmental Pollution 巻 266, p. 115094, 発行日 2020-11 |
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著者版フラグ | ||||||
値 | author |