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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

High levels of boron promote anchorage-independent growth of nontumorigenic cells

http://hdl.handle.net/2237/00033613
686c99fa-50d6-4e87-807d-ed006dd14ad3
名前 / ファイル ライセンス アクション
ENVIRONMENTAL_POLLUTION_2020_266_115094.pdf ENVIRONMENTAL_POLLUTION_2020_266_115094 (763.0 kB)
 Download is available from 2022/10/31.
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-15
タイトル
タイトル High levels of boron promote anchorage-independent growth of nontumorigenic cells
著者 Xu, Huadong

× Xu, Huadong

WEKO 103673

Xu, Huadong

Search repository
Hashimoto, Kazunori

× Hashimoto, Kazunori

WEKO 103674

Hashimoto, Kazunori

Search repository
Maeda, Masao

× Maeda, Masao

WEKO 103675

Maeda, Masao

Search repository
Azimi, Mohammad Daud

× Azimi, Mohammad Daud

WEKO 103676

Azimi, Mohammad Daud

Search repository
Fayaz, Said Hafizullah

× Fayaz, Said Hafizullah

WEKO 103677

Fayaz, Said Hafizullah

Search repository
Chen, Wei

× Chen, Wei

WEKO 103678

Chen, Wei

Search repository
Hamajima, Nobuyuki

× Hamajima, Nobuyuki

WEKO 103679

Hamajima, Nobuyuki

Search repository
Kato, Masashi

× Kato, Masashi

WEKO 103680

Kato, Masashi

Search repository
権利
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Boron
キーワード
主題Scheme Other
主題 Well drinking water
キーワード
主題Scheme Other
主題 Tumorigenic risk
キーワード
主題Scheme Other
主題 Tumorigenic pathway
抄録
内容記述 WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2022-11-01
内容記述タイプ Other
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.envpol.2020.115094
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0269-7491
書誌情報 Environmental Pollution

巻 266, p. 115094, 発行日 2020-11
著者版フラグ
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