{"_buckets": {"deposit": "addb6fc4-f0be-43aa-abf9-39fae509ce1e"}, "_deposit": {"id": "31433", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "31433"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00031433"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-11", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "115094", "bibliographicVolumeNumber": "266", "bibliographic_titles": [{"bibliographic_title": "Environmental Pollution"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 \u03bcM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 \u03bcM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2022-11-01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.envpol.2020.115094", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0269-7491", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Xu, Huadong"}], "nameIdentifiers": [{"nameIdentifier": "103673", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Kazunori"}], "nameIdentifiers": [{"nameIdentifier": "103674", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Masao"}], "nameIdentifiers": [{"nameIdentifier": "103675", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Azimi, Mohammad Daud"}], "nameIdentifiers": [{"nameIdentifier": "103676", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fayaz, Said Hafizullah"}], "nameIdentifiers": [{"nameIdentifier": "103677", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chen, Wei"}], "nameIdentifiers": [{"nameIdentifier": "103678", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hamajima, Nobuyuki"}], "nameIdentifiers": [{"nameIdentifier": "103679", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "103680", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-11-01"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2022/10/31.", "file_order": 0, "filename": "ENVIRONMENTAL_POLLUTION_2020_266_115094.pdf", "filesize": [{"value": "763.0 kB"}], "format": "application/pdf", "future_date_message": "Download is available from 2022/10/31.", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 763000.0, "url": {"label": "ENVIRONMENTAL_POLLUTION_2020_266_115094", "url": "https://nagoya.repo.nii.ac.jp/record/31433/files/ENVIRONMENTAL_POLLUTION_2020_266_115094.pdf"}, "version_id": "54e48fa8-87d3-4d41-bcda-89cbd40bd1e7"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Boron", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Well drinking water", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tumorigenic risk", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tumorigenic pathway", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "High levels of boron promote anchorage-independent growth of nontumorigenic cells", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "High levels of boron promote anchorage-independent growth of nontumorigenic cells"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00033613", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2021-02-15"}, "publish_date": "2021-02-15", "publish_status": "0", "recid": "31433", "relation": {}, "relation_version_is_last": true, "title": ["High levels of boron promote anchorage-independent growth of nontumorigenic cells"], "weko_shared_id": null}